Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

Author

SHEN, Y.-C^{1 2 3 4} ; OU, D.-L⁵ ; HSU, C^{2 4 6} ; LIN, K.-L⁴ ; CHANG, C.-Y⁴ ; LIN, C.-Y⁷ ; LIU, S.-H¹ ; CHENG, A.-L^{2 5 6}
[1] Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan, Province of China
[2] Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, Province of China
[3] Department Medical Research, National Taiwan University Hospital, Taipei, Taiwan, Province of China
[4] National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Province of China
[5] Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan, Province of China
[6] Department and Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Province of China
[7] Graduate Institute of Environmental Health, School of Public Health, National Taiwan University, Taipei, Taiwan, Province of China

Source

British journal of cancer. 2013, Vol 108, Num 1, pp 72-81, 10 p ; ref : 1 p.1/4

CODEN

BJCAAI

ISSN

0007-0920

Scientific domain

Medical oncology

Publisher

Nature Publishing Group, Basingstoke

Publication country

United Kingdom

Document type

Article

Language

English

Author keyword

dichloroacetate glycolysis hepatocellular carcinoma oxidative phosphorylation sorafenib

Keyword (fr)

Antiangiogénique Anticancéreux Cancer du foie Cancérologie Carcinome hépatocellulaire Glycolyse Phosphorylation oxydative Pyruvate dehydrogenase (lipoamide) Pyruvate kinase Résistance Sorafénib Cancer Enzyme Inhibiteur de la tyrosine kinase Inhibiteur enzyme Inhibiteur multikinase Oxidoreductases Pathologie de l'appareil digestif Pathologie du foie Transferases Tumeur maligne

Keyword (en)

Antiangiogenic agent Antineoplastic agent Liver cancer Cancerology Hepatocellular carcinoma Glycolysis Oxidative phosphorylation Pyruvate dehydrogenase (lipoamide) Pyruvate kinase Resistance Sorafenib Cancer Enzyme Tyrosine kinase inhibitor Enzyme inhibitor Multikinase inhibitor Oxidoreductases Digestive diseases Hepatic disease Transferases Malignant tumor

Keyword (es)

Antiangiogenico Anticanceroso Cáncer del hígado Cancerología Carcinoma hepatocelular Glicolisis Fosforilación oxidativa Pyruvate dehydrogenase (lipoamide) Pyruvate kinase Resistencia Sorafenib Cáncer Enzima Inhibidor tyrosine kinase Inhibidor enzima inhibidor multicinasa Oxidoreductases Aparato digestivo patología Hígado patología Transferases Tumor maligno

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C01 Tumors

Discipline

Gastroenterology. Liver. Pancreas. Abdomen Tumours

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

27073328

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS