A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity
- Author
- KOSTADINOVA, Radina1 ; BOESS, Franziska1 ; APPLEGATE, Dawn2 ; SUTER, Laura1 ; WEISER, Thomas1 ; SINGER, Thomas1 ; NAUGHTON, Brian2 ; ROTH, Adrian1
[1] Non-Clinical Safety, Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Building 73 / Room 117b, 4070 Basel, Switzerland
[2] RegeneMed, 9855 Towne Centre Drive Suite 200, San Diego, CA 92121, United States - Source
Toxicology and applied pharmacology. 2013, Vol 268, Num 1, pp 1-16, 16 p ; ref : 1 p.3/4
- CODEN
- TXAPA9
- ISSN
- 0041-008X
- Scientific domain
- Pharmacology drugs; Toxicology
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Cytochrome P450 Drug safety assessment Drug-induced liver injury Idiosyncratic toxicity Predictive toxicology Three-dimensional liver co-cultures
- Keyword (fr)
- Culture cellulaire mixte Cytochrome P450 Evaluation Facteur prédictif Foie Homme In vitro Long terme Médicament Pathologie du foie Prédiction Toxicité Toxicologie Appareil digestif Enzyme Pathologie de l'appareil digestif
- Keyword (en)
- Mixed cell culture Cytochrome P450 Evaluation Predictive factor Liver Human In vitro Long term Drug Hepatic disease Prediction Toxicity Toxicology Digestive system Enzyme Digestive diseases
- Keyword (es)
- Cultivo celular mixto Citocromo P450 Evaluación Factor predictivo Hígado Hombre In vitro Largo plazo Medicamento Hígado patología Predicción Toxicidad Toxicología Aparato digestivo Enzima Aparato digestivo patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U04 Toxicity: digestive system
- Discipline
- Drugs toxicity and drug intoxications Toxicology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 27194186
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1016/j.taap.2013.01.012 
https://dx.doi.org/10.1016/j.taap.2013.01.012
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.taap.2013.01.012\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:128:\"A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity\";s:9:\"\u0000*\u0000jtitle\";s:35:\"Toxicology and applied pharmacology\";s:9:\"\u0000*\u0000stitle\";s:24:\"Toxicol. appl. pharmacol\";s:7:\"\u0000*\u0000date\";s:4:\"2013\";s:9:\"\u0000*\u0000volume\";s:3:\"268\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:1:\"1\";s:8:\"\u0000*\u0000epage\";s:2:\"16\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0041-008X\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:11:\"KOSTADINOVA\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Radina\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:16:\"BOESS, Franziska\";i:1;s:15:\"APPLEGATE, Dawn\";i:2;s:12:\"SUTER, Laura\";i:3;s:14:\"WEISER, Thomas\";i:4;s:14:\"SINGER, Thomas\";i:5;s:15:\"NAUGHTON, Brian\";i:6;s:12:\"ROTH, Adrian\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"TXAPA9\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:128:\"A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity\";s:8:\"\u0000*\u0000place\";s:9:\"Amsterdam\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"16\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.taap.2013.01.012\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:128:\"A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity\";s:9:\"\u0000*\u0000jtitle\";s:35:\"Toxicology and applied pharmacology\";s:9:\"\u0000*\u0000stitle\";s:24:\"Toxicol. appl. pharmacol\";s:7:\"\u0000*\u0000date\";s:4:\"2013\";s:9:\"\u0000*\u0000volume\";s:3:\"268\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:1:\"1\";s:8:\"\u0000*\u0000epage\";s:2:\"16\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0041-008X\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:11:\"KOSTADINOVA\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Radina\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:16:\"BOESS, Franziska\";i:1;s:15:\"APPLEGATE, Dawn\";i:2;s:12:\"SUTER, Laura\";i:3;s:14:\"WEISER, Thomas\";i:4;s:14:\"SINGER, Thomas\";i:5;s:15:\"NAUGHTON, Brian\";i:6;s:12:\"ROTH, Adrian\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"TXAPA9\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:128:\"A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity\";s:8:\"\u0000*\u0000place\";s:9:\"Amsterdam\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"16\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.taap.2013.01.012\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.taap.2013.01.012\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:128:\"A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity\";s:9:\"\u0000*\u0000jtitle\";s:35:\"Toxicology and applied pharmacology\";s:9:\"\u0000*\u0000stitle\";s:24:\"Toxicol. appl. pharmacol\";s:7:\"\u0000*\u0000date\";s:4:\"2013\";s:9:\"\u0000*\u0000volume\";s:3:\"268\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:1:\"1\";s:8:\"\u0000*\u0000epage\";s:2:\"16\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0041-008X\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:11:\"KOSTADINOVA\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Radina\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:16:\"BOESS, Franziska\";i:1;s:15:\"APPLEGATE, Dawn\";i:2;s:12:\"SUTER, Laura\";i:3;s:14:\"WEISER, Thomas\";i:4;s:14:\"SINGER, Thomas\";i:5;s:15:\"NAUGHTON, Brian\";i:6;s:12:\"ROTH, Adrian\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"TXAPA9\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:128:\"A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity\";s:8:\"\u0000*\u0000place\";s:9:\"Amsterdam\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"16\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.taap.2013.01.012\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:128:\"A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity\";s:9:\"\u0000*\u0000jtitle\";s:35:\"Toxicology and applied pharmacology\";s:9:\"\u0000*\u0000stitle\";s:24:\"Toxicol. appl. pharmacol\";s:7:\"\u0000*\u0000date\";s:4:\"2013\";s:9:\"\u0000*\u0000volume\";s:3:\"268\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:1:\"1\";s:8:\"\u0000*\u0000epage\";s:2:\"16\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0041-008X\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:11:\"KOSTADINOVA\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Radina\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:16:\"BOESS, Franziska\";i:1;s:15:\"APPLEGATE, Dawn\";i:2;s:12:\"SUTER, Laura\";i:3;s:14:\"WEISER, Thomas\";i:4;s:14:\"SINGER, Thomas\";i:5;s:15:\"NAUGHTON, Brian\";i:6;s:12:\"ROTH, Adrian\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"TXAPA9\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:128:\"A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity\";s:8:\"\u0000*\u0000place\";s:9:\"Amsterdam\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"16\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
