Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1―BCR-ABL―JAK2 Complex
- Author
- MIN CHEN1 ; GALLIPOLI, Paolo3 ; LAMBIE, Karen1 ; NAKAMOTO, Helen1 ; KYI MIN SAW1 ; TURHAN, Ali7 ; ARLINGHAUS, Ralph8 ; PAUL, James4 ; STOBO, Jon4 ; BARNETT, Michael J2 5 ; EAVES, Allen1 5 ; EAVES, Connie J1 5 6 ; DEGEER, Donna1 ; HOLYOAKE, Tessa L3 ; XIAOYAN JIANG1 5 6 ; SLOMA, Ivan1 ; FORREST, Donna L2 5 ; CHAN, Matthew1 ; DAMIAN LAI1 ; JORGENSEN, Heather3 ; RINGROSE, Ashley1 ; HUI MI WANG1
[1] Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
[2] Leukemia/BMT Program of British Columbia, Division of Hematology, British Columbia Cancer Agency, Vancouver, BC, Canada
[3] Paul O'Gorman Leukemia Research Centre, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
[4] Cancer Research UK Clinical Trials Unit, University of Glasgow, Glasgow, United Kingdom
[5] Department of Medicine, University of British Columbia, Vancouver, BC, Canada
[6] Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
[7] Department of Hematology and Biological Oncology, University of Poitiers, INSERM U935, Poitiers, France
[8] Department of Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States - Source
Journal of the National Cancer Institute. 2013, Vol 105, Num 6, pp 405-423, 19 p ; ref : 70 ref
- ISSN
- 0027-8874
- Scientific domain
- Medical oncology
- Publisher
- Oxford University Press, Cary, NC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cancérologie Cellule Chromosome C9 anormal Chromosome G22 anormal Chromosome Ph1 Ciblage Complexité Efficacité Gène hybride Gène onc cellulaire Inhibiteur Inhibition Leucémie myéloïde chronique Non-specific serine/threonine protein kinase Primitif Protein-tyrosine kinase Translocation chromosomique Gène Ahi1 Gène abl1 Gène abl Gène bcr JAK2 protein tyrosine kinase Aberration chromosomique Cancer Chromosome anormal Enzyme Hémopathie maligne Syndrome myéloprolifératif Transferases
- Keyword (en)
- Cancerology Cell Abnormal chromosome C9 Abnormal chromosome G22 Philadelphia chromosome Targeting Complexity Efficiency Hybrid gene C-Onc gene Inhibitor Inhibition Chronic myelogenous leukemia Non-specific serine/threonine protein kinase Primitive Protein-tyrosine kinase Chromosome translocation Abl1 gene bcr gene JAK2 protein tyrosine kinase Chromosomal aberration Cancer Abnormal chromosome Enzyme Malignant hemopathy Myeloproliferative syndrome Transferases
- Keyword (es)
- Cancerología Célula Cromosoma C9 anormal Cromosoma G22 anormal Cromosoma Ph1 Blancado Complejidad Eficacia Gen híbrido Gen onc celular Inhibidor Inhibición Leucemia mieloidea crónica Non-specific serine/threonine protein kinase Primitivo Protein-tyrosine kinase Translocación cromosómica JAK2 protein tyrosine kinase Aberración cromosómica Cáncer Cromosoma anormal Enzima Hemopatía maligna Mieloproliferativo síndrome Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 27317171
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1093/jnci/djt006 
https://dx.doi.org/10.1093/jnci/djt006
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