The Investigational Aurora Kinase A Inhibitor MLN8237 Induces Defects in Cell Viability and Cell-Cycle Progression in Malignant Bladder Cancer Cells In Vitro and In Vivo
- Author
- NING ZHOU1 ; SINGH, Kamini2 ; HANSEL, Donna E1 3 4 5 ; MIR, Maria C1 ; PARKER, Yvonne5 ; LINDNER, Daniel5 ; DREICER, Robert5 ; ECSEDY, Jeffrey A6 ; ZHONGFA ZHANG7 ; TEH, Bin T8 ; ALMASAN, Alexandru2
[1] Pathology and Laboratory Medicine Institute, United States
[2] Lerner Research Institute, United States
[3] Glickman Urological and Kidney Institute, United States
[4] Genomic Medicine Institute, United States
[5] Department of Solid Tumor Oncology, Cleveland Clinic, Cleveland, Ohio, United States
[6] Millennium Pharmaceuticals, Cambridge, Massachusetts, United States
[7] Van Andel Research Institute, Grand Rapids, Michigan, United States
[8] NCCS-VARI Translational Research Laboratory, National Cancer Center, Singapore, Singapore - Source
Clinical cancer research (Print). 2013, Vol 19, Num 7, pp 1717-1728, 12 p ; ref : 50 ref
- CODEN
- CCREF4
- ISSN
- 1078-0432
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cancer de la vessie Cellule tumorale Cycle cellulaire Défaut In vitro In vivo Inhibiteur Transformation maligne Viabilité Aurora kinase Serine/threonine-protein kinase 6 Cancer Pathologie de l'appareil urinaire Pathologie de la vessie Pathologie des voies urinaires Tumeur maligne
- Keyword (en)
- Bladder cancer Tumor cell Cell cycle Defect In vitro In vivo Inhibitor Malignant transformation Viability Aurora kinase Serine/threonine-protein kinase 6 Cancer Urinary system disease Bladder disease Urinary tract disease Malignant tumor
- Keyword (es)
- Cáncer de la vejiga Célula tumoral Ciclo celular Defecto In vitro In vivo Inhibidor Transformación maligna Viabilidad Cáncer Aparato urinario patología Vejiga patología Vía urinaria patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B14 Nephrology. Urinary tract diseases / 002B14D Tumors of the urinary system / 002B14D02 Urinary tract. Prostate gland
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B14 Nephrology. Urinary tract diseases / 002B14E Urinary system involvement in other diseases. Miscellaneous / 002B14E02 Urinary tract. Prostate gland
- Discipline
- Nephrology. Urinary tract diseases Pharmacological treatments Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 27382924
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/1078-0432.CCR-12-2383 
https://dx.doi.org/10.1158/1078-0432.CCR-12-2383
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