Conformational flexibility of serotonin1A receptor ligands from crystallographic data. Updated model of the receptor pharmacophore
- Author
- CHILMONCZYK, Z1 ; SZELEJEWSKA-WOZNIAKOWSKA, A1 ; CYBULSKI, J1 ; CYBULSKI, M1 ; KOZIOŁ, A. E2 ; GDANIEC, M3
[1] Pharmaceutical Research Institute, 8 Rydygiera St., 01-793 Warszawa, Poland
[2] Faculty of Chemistry, Maria Curie-Sklodowska University, 3 Maria Curie-Sklodowska Square, 20-031 Lublin, Poland
[3] Faculty of Chemistry, Adam Mickiewicz University, 6 Grunwaldzka St., 60-780 Poznan, Poland - Source
Archiv der Pharmazie (Weinheim). 1997, Vol 330, Num 5, pp 146-160 ; ref : 45 ref
- CODEN
- ARPMAS
- ISSN
- 0365-6233
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Wiley-VCH, Weinheim
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Analyse conformationnelle Hétérocycle azote Imide Lactame Ligand Modèle moléculaire Modélisation Pipérazine dérivé Pipéridine dérivé Quinoléine dérivé Relation structure activité Récepteur sérotoninergique 5-HT1A Structure cristalline 4,7-Ethanoisoindole-1,3-dione(perhydro-2-[4-(4-[2-quinolyl]pipérazino)butyl]) 4,7-Ethénoisoindole-1,3-dione(perhydro-2-[4-(4-[2-quinolyl]pipérazino)butyl]) 4,7-Méthanoisoindole-1,3-dione(perhydro-2-[4-(4-[2-quinolyl]pipérazino)butyl]) Pharmacophore Pipéridin-2-one(1-[4-(4-[2-quinolyl]pipérazino)butyl])
- Keyword (en)
- Affinity Conformational analysis Nitrogen heterocycle Imide Lactam Ligand Molecular model Modeling Piperazine derivatives Piperidine derivatives Quinoline derivatives Structure activity relation 5-HT1A receptor Crystalline structure
- Keyword (es)
- Afinidad Análisis conformacional Heterociclo nitrógeno Imida Lactamo Ligando Modelo molecular Modelización Piperazina derivado Piperidina derivado Quinolina derivado Relación estructura actividad Receptor serotoninérgico 5-HT1A Estructura cristalina
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09C Serotoninergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2742947
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/ardp.19973300507 
https://dx.doi.org/10.1002/ardp.19973300507
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