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Lack of a Pharmacokinetic Interaction Between Treprostinil Diolamine and Sildenafil in Healthy Adult Volunteers

Author
GOTZKOWSKY, S. Karl1 ; KUMAR, Parag1 ; MOTTOLA, David1 ; LALIBERTE, Kevin1
[1] Product Development, United Therapeutics Corporation, Research Triangle Park, NC, United States
Source

Journal of cardiovascular pharmacology. 2013, Vol 61, Num 5, pp 444-451, 8 p ; ref : 23 ref

CODEN
JCPCDT
ISSN
0160-2446
Scientific domain
Cardiology, blood circulation, phlebology; Pharmacology drugs
Publisher
Lippincott, Hagerstown, MD
Publication country
United States
Document type
Article
Language
English
Author keyword
pharmacokinetics pulmonary arterial hypertension revatio sildenafil treprostinil
Keyword (fr)
Diolamine Homme Hypertension artérielle pulmonaire Individu sain Interaction Pharmacocinétique Sildénafil Tréprostinil Vasodilatateur Prostacycline 3',5'-Cyclic-GMP phosphodiesterase Enzyme Esterases Hydrolases Inhibiteur de la phosphodiesterase Inhibiteur de la phosphodiestérase 5 Inhibiteur enzyme Pathologie de l'appareil circulatoire Pathologie de l'appareil respiratoire Phosphoric diester hydrolases Prostaglandine I2
Keyword (en)
Diolamine Human Pulmonary hypertension Healthy subject Interaction Pharmacokinetics Sildenafil Treprostinil Vasodilator agent 3',5'-Cyclic-GMP phosphodiesterase Enzyme Esterases Hydrolases Phosphodiesterase inhibitor Phosphodiesterase 5 inhibitor Enzyme inhibitor Cardiovascular disease Respiratory disease Phosphoric diester hydrolases Prostaglandin I2
Keyword (es)
Diolamina Hombre Hipertensión arterial pulmonar Individuo sano Interacción Farmacocinética Sildenafilo Treprostinilo Vasodilatador 3',5'-Cyclic-GMP phosphodiesterase Enzima Esterases Hydrolases Inhibidor phosphodiesterase Inhibidor fosfodiesterasa 5 Inhibidor enzima Aparato circulatorio patología Aparato respiratorio patología Phosphoric diester hydrolases Prostaglandina I2
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B11 Pneumology / 002B11C Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases

Discipline
Pharmacological treatments Pulmonology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
27450362

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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