Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen
- Author
- ADLINGTON, R. M1 ; BALDWIN, J. E1 ; NEUBAUER, B. L3 ; CHEN, B1 ; COOPER, S. L1 ; MCCOULL, W1 ; PRITCHARD, G. J1 ; HOWE, T. J2 ; BECKER, G. W3 ; HERMANN, R. B3 ; MCNULTY, A. M3
[1] The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, United Kingdom
[2] Lilly Research Centre Ltd, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, United Kingdom
[3] Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, United States - Source
Bioorganic & medicinal chemistry letters (Print). 1997, Vol 7, Num 13, pp 1689-1694
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Anticancéreux Antigène spécifique prostate Azétidine dérivé Carboxamide Ciblage Complexe enzyme inhibiteur Composé benzénique Cycle 4 chaînons Ester Hétérocycle azote In vitro Inhibiteur Lactame Modèle moléculaire Modélisation Promédicament Relation structure activité Site actif Synthèse chimique Azétidine-2-carboxylique acide(3-benzyl-1-[3-(4-carboxybenzyloxycarbonyl)phénylacétyl]-4-oxo) ester 4-[carboxy]benzyle
- Keyword (en)
- Carboxylic acid Antineoplastic agent Prostate specific antigen Azetidine derivatives Carboxamide Targeting Inhibitor enzyme complex Benzenic compound Four membered ring Ester Nitrogen heterocycle In vitro Inhibitor Lactam Molecular model Modeling Prodrug Structure activity relation Active site Chemical synthesis
- Keyword (es)
- Acido carboxílico Anticanceroso Antigeno específico prostata Carboxamida Blancado Complejo enzima inhibidor Compuesto bencénico Ciclo 4 eslabones Ester Heterociclo nitrógeno In vitro Inhibidor Lactamo Modelo molecular Modelización Promedicamento Relación estructura actividad Lugar activo Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2746707
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0960-894X(97)00285-0 
https://dx.doi.org/10.1016/S0960-894X(97)00285-0
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