The hydroxyl epimer of doxorubicin controls the rate of formation of cytotoxic anthracycline-DNA adducts
- Author
- FORREST, Robert A1 ; SWIFT, Lonnie P2 ; EVISON, Benny J1 ; REPHAELI, Ada3 ; NUDELMAN, Abraham4 ; PHILLIPS, Don R1 ; CUTTS, Suzanne M1
[1] La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia
[2] Department of Oncology, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom
[3] Felsenstein Medical Research Centre, Sackler School of Medicine, Tel Aviv University, 49100 Petach Tikva, Israel
[4] Chemistry Department, Bar Ilan University, 52900 Ramat Gan, Israel - Source
Cancer chemotherapy and pharmacology. 2013, Vol 71, Num 3, pp 809-816, 8 p ; ref : 20 ref
- CODEN
- CCPHDZ
- ISSN
- 0344-5704
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, Heidelberg
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- DNA damage Drug―DNA adduct Epirubicin Formaldehyde p53
- Keyword (fr)
- Adduit moléculaire Anthracyclines Anticancéreux Cytotoxicité Doxorubicine Epirubicine Formaldéhyde Gène TP53 Gène suppresseur tumeur Hydroxyle Lésion Médicament Gène p53 DNA topoisomerase (ATP-hydrolysing) Enzyme Inhibiteur de la topoisomérase II Inhibiteur enzyme Isomerases
- Keyword (en)
- Molecular adduct Anthracyclins Antineoplastic agent Cytotoxicity Doxorubicin Epirubicin Formaldehyde TP53 Gene Tumor suppressor gene Hydroxyl Lesion Drug DNA topoisomerase (ATP-hydrolysing) Enzyme Topoisomerase II inhibitor Enzyme inhibitor Isomerases
- Keyword (es)
- Producto adición molecular Antraciclinas Anticanceroso Citotoxicidad Doxorubicina Epirubicina Formaldehído Gen TP53 Gen supresor tumor Hidroxilo Lesión Medicamento DNA topoisomerase (ATP-hydrolysing) Enzima Inhibidor topoisomerase II Inhibidor enzima Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 27610404
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s00280-012-2049-x 
https://dx.doi.org/10.1007/s00280-012-2049-x
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