A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease―Drug Interactions: Suppression of CYP3A by IL-6
- Author
- MACHAVARAM, K. K1 ; ALMOND, L. M1 ; ROSTAMI-HODJEGAN, A1 2 ; GARDNER, I1 ; JAMEI, M1 ; TAY, S3 ; WONG, S3 ; JOSHI, A4 ; KENNY, J. R3
[1] Simcyp (a Certara Company), Sheffield, United Kingdom
[2] School of Pharmacy and Pharmaceutical Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom
[3] Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, California, United States
[4] Department of Clinical Pharmacology, Genentech, South San Francisco, California, United States - Source
Clinical pharmacology and therapeutics. 2013, Vol 94, Num 2, pp 260-268, 9 p ; ref : 38 ref
- CODEN
- CLPTAT
- ISSN
- 0009-9236
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cytochrome P450 Facteur prédictif Homme Interaction médicamenteuse Interleukine 6 Isozyme Maladie Modélisation Pharmacocinétique Suppression Cytochrome P450 3A Cytokine Enzyme
- Keyword (en)
- Cytochrome P450 Predictive factor Human Drug interaction Interleukin 6 Isozyme Disease Modeling Pharmacokinetics Suppression Cytokine Enzyme
- Keyword (es)
- Citocromo P450 Factor predictivo Hombre Interacción medicamentosa Interleuquina 6 Isozima Enfermedad Modelización Farmacocinética Supresión Citoquina Enzima
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 27614983
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/clpt.2013.79 
https://dx.doi.org/10.1038/clpt.2013.79
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