Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients

Author

HYE RYUN KIM^{1 2} ; HYUNG SOON PARK³ ; WOO SUN KWON^{4 5} ; JI HYUN LEE^{3 6} ; TANIGAWARA, Yusuke⁷ ; SUN MIN LIM^{1 2} ; HYO SONG KIM^{1 2} ; SANG JUN SHIN^{1 2} ; JUNG BAE AHN^{1 2} ; SUN YOUNG RHA¹
[1] Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea, Republic of
[2] Division of Medical Oncology, Yonsei Cancer Center, College of Medicine, Yonsei University, 50 Yonsei-ro, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea, Republic of
[3] Department of Pharmacology, Pharmacogenomic Research Center for Membrane Transporters, College of Medicine, Yonsei University, Seoul, Korea, Republic of
[4] Cancer Metastasis Research Center, College of Medicine, Yonsei University, Seoul, Korea, Republic of
[5] Brain Korea 21 Project for Medical Sciences, College of Medicine, Yonsei University, Seoul, Korea, Republic of
[6] Research Center for Human Natural Defense System, College of Medicine, Yonsei University, Seoul, Korea, Republic of
[7] Department of Clinical Pharmacokinetics and Pharmacodynamics, School of Medicine, Keio University, Minato, Japan

Source

Cancer chemotherapy and pharmacology. 2013, Vol 72, Num 4, pp 825-835, 11 p ; ref : 37 ref

CODEN

CCPHDZ

ISSN

0344-5704

Scientific domain

Medical oncology; Pharmacology drugs

Publisher

Springer, Heidelberg

Publication country

Germany

Document type

Article

Language

English

Author keyword

Polymorphism Renal cell carcinoma Sunitinib Toxicity

Keyword (fr)

Antiangiogénique Anticancéreux Cancer rein Carcinome Ethnie Génotype Homme Hypernéphrome Métastase Origine ethnique Pharmacogénétique Polymorphisme Stade avancé Sunitinib Toxicité Variabilité génétique Corée Cancer Enzyme Génétique Inhibiteur de la tyrosine kinase Inhibiteur enzyme Inhibiteur multikinase Pathologie de l'appareil urinaire Pathologie du rein Protein-tyrosine kinase Transferases Tumeur maligne Asie

Keyword (en)

Antiangiogenic agent Antineoplastic agent Kidney cancer Carcinoma Ethnic group Genotype Human Grawitz tumor Metastasis Ethnic origin Pharmacogenetics Polymorphism Advanced stage Sunitinib Toxicity Genetic variability Korea Cancer Enzyme Genetics Tyrosine kinase inhibitor Enzyme inhibitor Multikinase inhibitor Urinary system disease Kidney disease Protein-tyrosine kinase Transferases Malignant tumor Asia

Keyword (es)

Antiangiogenico Anticanceroso Cáncer del riñón Carcinoma Etnia Genotipo Hombre Hipernefroma Metástasis Origen étnico Farmacogenética Polimorfismo Estadio avanzado Sunitinib Toxicidad Variabilidad genética Corea Cáncer Enzima Genética Inhibidor tyrosine kinase Inhibidor enzima inhibidor multicinasa Aparato urinario patología Riñón patología Protein-tyrosine kinase Transferases Tumor maligno Asia

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B14 Nephrology. Urinary tract diseases / 002B14D Tumors of the urinary system / 002B14D01 Kidneys

Discipline

Nephrology. Urinary tract diseases Pharmacological treatments Tumours

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

27779117

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS