A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma
- Author
- BEATTY, Gregory L1 2 ; TORIGIAN, Drew A1 3 ; O'DWYER, Peter J1 2 ; GABRIELA CHIOREAN, E7 ; SABOURY, Babak3 ; BROTHERS, Alex3 ; ALAVI, Abass3 ; TROXEL, Andrea B1 4 ; WEIJING SUN6 ; TEITELBAUM, Ursina R1 2 ; VONDERHEIDE, Robert H1 2 5
[1] Abramson Cancer Center, University of Pennsylvania, Philadelphia, United States
[2] Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, United States
[3] Departments of Radiology, University of Pennsylvania, Philadelphia, United States
[4] Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, United States
[5] Abramson Family Cancer Research Institute, United States
[6] University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States
[7] University of Washington, Seattle, Washington, United States - Source
Clinical cancer research (Print). 2013, Vol 19, Num 22, pp 6286-6295, 10 p ; ref : 30 ref
- CODEN
- CCREF4
- ISSN
- 1078-0432
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Adénocarcinome canalaire du pancréas Agoniste Anticancéreux Anticorps monoclonal Association médicamenteuse Cancer du pancréas Essai clinique phase I Gemcitabine Homme Pharmacocinétique Stade avancé Toxicité Traitement Antigène CD40 Antimétabolite Cancer Dérivé de la pyrimidine Fluor Composé organique Pathologie de l'appareil digestif Pathologie du pancréas Pyrimidine nucléoside Tumeur maligne
- Keyword (en)
- Pancreas ductal adenocarcinoma Agonist Antineoplastic agent Monoclonal antibody Drug combination Pancreas cancer Phase I trial Gemcitabine Human Pharmacokinetics Advanced stage Toxicity Treatment Antimetabolic Cancer Pyrimidine derivatives Fluorine Organic compounds Digestive diseases Pancreatic disease Pyrimidine nucleoside Malignant tumor
- Keyword (es)
- Adenocarcinoma ductal de páncreas Agonista Anticanceroso Anticuerpo monoclonal Asociación medicamentosa Cáncer del páncreas Ensayo clínico fase I Gemcitabina Hombre Farmacocinética Estadio avanzado Toxicidad Tratamiento Antimetabólito Cáncer Pirimidina derivado Fluor Compuesto orgánico Aparato digestivo patología Páncreas patología Pirimidina nucleósido Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Pharmacological treatments Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 27962133
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/1078-0432.CCR-13-1320 
https://dx.doi.org/10.1158/1078-0432.CCR-13-1320
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