Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
- Author
- DE LA TORRE, Rafael1 2 3 ; DE SOLA, Susana1 ; PUJADAS, Mitona1 2 ; BIZOT, Jean Charles10 ; CUENCA, Aída1 11 ; JANEL, Nathalie12 ; CATUARA, Silvina4 5 ; COVAS, Maria Isabel2 ; BLEHAUT, Henri13 ; HERAULT, Yann6 ; DELABAR, Jean Marie11 ; DIERSSEN, Mara3 4 5 ; PONS, Meritxell3 4 5 ; DUCHON, Arnaud6 ; DE LAGRAN, María Martíez3 4 5 ; FARRE, Magí1 7 ; FITO, Montserrat2 ; BENEJAM, Bessy8 ; LANGOHR, Klaus1 9 ; RODRIGUEZ, Joan1
[1] Human Pharmacology and Clinical Neurosciences Research Group-Neurosciences Program, IMIM-Hospital del Mar Research Institute, Barcelona, Spain
[2] Cardiovascular Risk and Nutrition Research Group-Inflammatory and Cardiovascular Disorders Program, IMIM-Hospital del Mar Research Institute, and CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Barcelona, Spain
[3] University Pompeu Fabra, CEXS-UPF, Barcelona, Spain
[4] Center for Genomic Regulation (CRG), Spain
[5] CIBER de Enfermedades Raras (CIBERER), Barcelona, Spain
[6] Institut de Génétique et de Biologie Moléculaire et Cellulaire, Translational Medicine and Neuroscience Program, IGBMC, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, and Institut Clinique de la Souris, ICS, GIE CERBM, Illkirch, France
[7] Universitat Autònoma de Barcelona (UDIMAS-UAB), Barcelona, Spain
[8] Fundació Catalana Sindrome de Down, Barcelona, Spain
[9] Department of Statistics and Operations Research, Universitat Politècnica de Catalunya, Barcelona, Spain
[10] Key-Obs S.A., Allée du Titane, Orléans, France
[11] Epidemiology of Drugs of Abuse Research Group-Epidemiology and Public Health Program, IMIM-Hospital del Mar Research Institute, Barcelona, Spain
[12] Adaptive Functional Biology, EAC CNRS, University Paris Diderot, Sorbonne Paris Cité, Paris, France
[13] Jérôme Lejeune Foundation, Paris, France - Source
Molecular nutrition & food research (Print). 2014, Vol 58, Num 2, pp 278-288, 11 p ; ref : 42 ref
- ISSN
- 1613-4125
- Scientific domain
- Food science technology
- Publisher
- Wiley, Weinheim
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Cognition DYRK1A Down syndrome Epigallocatechin gallate Homocysteine
- Keyword (fr)
- Acide gallique Animal Chromosome G21 Cognition Homme Homocystéine Inhibiteur Modèle animal Nutrition Sauvetage Souris Syndrome de Down Trisomie Trouble cognitif Epigallocatéchine-3-gallate Aberration chromosomique Aminoacide soufré Aneuploïdie Mammalia Rodentia Thiol Vertebrata
- Keyword (en)
- Gallic acid Animal Chromosome G21 Cognition Human Homocystein Inhibitor Animal model Nutrition Rescue Mouse Down syndrome Trisomy Cognitive disorder Epigallocatechin-3-gallate Chromosomal aberration Sulfur containing aminoacid Aneuploidy Mammalia Rodentia Thiol Vertebrata
- Keyword (es)
- Gálico ácido Animal Cromosoma G21 Cognición Hombre Homocisteína Inhibidor Modelo animal Nutrición Salvamento Ratón Mongolismo Trisomía Trastorno cognitivo Epigalocatequina-3-galato Aberración cromosómica Aminoácido azufrado Aneuploidía Mammalia Rodentia Tiol Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A16 Vertebrates: anatomy and physiology, studies on body, several organs or systems / 002A16E Feeding. Feeding behavior
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B23 Medical genetics / 002B23B Chromosome aberrations
- Discipline
- Medical genetics Vertebrates : anatomy and physiology, studies on body, several organs or systems
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 28212746
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/mnfr.201300325 
https://dx.doi.org/10.1002/mnfr.201300325
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