A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer
- Author
- VALTORTA, Silvia1 2 ; NICOLINI, Gabriella3 ; PAGLIARIN, Roberto8 ; ORSINI, Fulvia8 ; MORESCO, Rosa Maria2 ; COCCETTI, Paola4 ; TRIPODI, Farida4 5 ; MEREGALLI, Cristina3 ; CAVALETTI, Guido3 ; AVEZZA, Federica3 ; CRIPPA, Luca6 ; BERTOLI, Gloria1 ; SANVITO, Francesca7 ; FUSI, Paola5
[1] IBFM-CNR, Segrate, Milan, Italy
[2] Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, Italy
[3] Experimental Neurology Unit Department of Surgery and Translational Medicine, University of Milano-Bicocca, Monza, Italy
[4] SYSBIO, Centre of Systems Biology, Milan, Italy
[5] Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
[6] Istovet - Laboratories of Veterinary Histopathology, Monza, Italy
[7] Mouse Histopathology Unit, Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy
[8] Department of Chemistry, University of Milan, Milan, Italy - Source
Investigational new drugs. 2014, Vol 32, Num 6, pp 1123-1133, 11 p ; ref : 37 ref
- CODEN
- INNDDK
- ISSN
- 0167-6997
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- Springer, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- Azetidinones Colorectal cancer Combretastatin A4 (CA-4) PET Xenograft
- Keyword (fr)
- Animal Anticancéreux Calcium Cancer colorectal Dérivé de l'azétidine Glucose Inhibiteur Modèle animal Mécanisme action Progression carcinogenèse Souris Traitement Activateur de l'AMPK Combrétastatine A-4 Cancer Chirurgie Combrétastatine dérivé Elément minéral Mammalia Pathologie de l'appareil digestif Pathologie de l'intestin Pathologie du côlon Pathologie du rectum Rodentia Tumeur maligne Vertebrata
- Keyword (en)
- Animal Antineoplastic agent Calcium Colorectal cancer Azetidine derivatives Glucose Inhibitor Animal model Mechanism of action Tumor progression Mouse Treatment AMPK activator Cancer Surgery Combretastatin derivative Inorganic element Mammalia Digestive diseases Intestinal disease Colonic disease Rectal disease Rodentia Malignant tumor Vertebrata
- Keyword (es)
- Animal Anticanceroso Calcio Cancer de colon y recto Glucosa Inhibidor Modelo animal Mecanismo acción Progresión carcinogénesis Ratón Tratamiento Cáncer Cirugía Combretastatina derivado Elemento inorgánico Mammalia Aparato digestivo patología Intestino patología Colón patología Recto patología Rodentia Tumor maligno Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 29026923
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s10637-014-0148-8 
https://dx.doi.org/10.1007/s10637-014-0148-8
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