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Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits

Author
SILVERWOOD, Richard J1 2 3 ; HOLMES, Michael V3 4 ; CASAS, Juan P1 10 ; DUDBRIDE, Frank1 2 3 ; DALE, Caroline E1 ; LAWLOR, Debbie A5 6 ; WHITTAKER, John C1 7 ; SMITH, George Davey5 6 ; LEON, David A1 ; PALMER, Tom8 ; KEATING, Brendan J9 ; ZUCCOLO, Luisa5 6
[1] Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
[2] Centre for Statistical Methodology, London School of Hygiene and Tropical Medicine, London, United Kingdom
[3] Bloomsbury Centre for Genetic Epidemiology and Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom
[4] Department of Epidemiology and Public Health, University College London, London, United Kingdom
[5] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
[6] School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
[7] Genetics, R & D, GlaxoSmithKline, Stevenage, United Kingdom
[8] Division of Health Sciences, University of Warwick, Warwick, Coventry, United Kingdom
[9] Center for Applied Genomics, Abramson Research Center, Children's Hospital of Philadelphia, Philadelphia, PA, United States
[10] Institute of Cardiovascular Science, University College London, London, United Kingdom
Alcohol-ADH1B Consortium
Source

International journal of epidemiology. 2014, Vol 43, Num 6, pp 1781-1790, 10 p ; ref : 29 ref

CODEN
IJEPBF
ISSN
0300-5771
Scientific domain
Hygiene and public health, epidemiology, occupational medicine
Publisher
Oxford University Press, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Mendelian randomization alcohol consumption cardiovascular disease causal inference instrumental variables local average treatment effects
Keyword (fr)
Analyse statistique Appareil circulatoire Application Boisson alcoolisée Cause Consommation Dépistage Ethanol Génotype Inférence Méthode statistique Pathologie de l'appareil circulatoire Randomisation Santé publique Traitement Typage Variable instrumentale
Keyword (en)
Statistical analysis Circulatory system Application Alcoholic beverage Cause Consumption Medical screening Ethanol Genotype Inference Statistical method Cardiovascular disease Randomization Public health Treatment Typing Instrumental variable
Keyword (es)
Análisis estadístico Aparato circulatorio Aplicación Bebida alcohólica Causa Consumo Descubrimiento Etanol Genotipo Inferencia Método estadístico Aparato circulatorio patología Aleatorización Salud pública Tratamiento Tipificación Variable instrumental
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B30 Public health. Hygiene-occupational medicine / 002B30A Public health. Hygiene / 002B30A03 Prevention and actions

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B30 Public health. Hygiene-occupational medicine / 002B30A Public health. Hygiene / 002B30A11 Miscellaneous

Discipline
Public health. Hygiene-occupational medicine
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
29086450

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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