Preparation of 5-aminomethyl-1,6-dihydro-2-methyl-6-oxo-3,4'-bipyridine (tetrahydromilrinone) : a potential affinity ligand for cGMP-inhibited cyclic nucleotide phosphodiesterase
- Author
- BELTMAN, J1 ; GREEN, J. R; MUTUS, B
[1] ONYX Pharmaceuticals, Richmond CA 94806, United States - Source
Microchemical journal. 1995, Vol 52, Num 3, pp 320-324 ; ref : 10 ref
- CODEN
- MICJAN
- ISSN
- 0026-265X
- Scientific domain
- Analytical chemistry
- Publisher
- Elsevier, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- 3',5'-Cyclic-nucleotide phosphodiesterase Activité biologique Amine primaire Cycle 6 chaînons Hydrogénation Hétérocycle azote Lactame Ligand Nitrile Purification Pyridine dérivé Réaction catalytique Synthèse chimique 3,4p-Bipyridyl-2-one(5-aminométhyl-2-méthyl-1,4,5,6-tétrahydro) 3,4p-Bipyridyle-5-carbonitrile(1,6-dihydro-2-méthyl-6-oxo) Enzyme Esterases Hydrolases Phosphoric diester hydrolases
- Keyword (en)
- 3',5'-Cyclic-nucleotide phosphodiesterase Biological activity Primary amine Six membered ring Hydrogenation Nitrogen heterocycle Lactam Ligand Nitrile Purification Pyridine derivatives Catalytic reaction Chemical synthesis Enzyme Esterases Hydrolases Phosphoric diester hydrolases
- Keyword (es)
- 3',5'-Cyclic-nucleotide phosphodiesterase Actividad biológica Amina primaria Ciclo 6 eslabones Hidrogenación Heterociclo nitrógeno Lactamo Ligando Nitrilo Purificación Piridina derivado Reacción catalítica Síntesis química Enzima Esterases Hydrolases Phosphoric diester hydrolases
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06C Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2934356
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1006/mchj.1995.1103 
https://dx.doi.org/10.1006/mchj.1995.1103
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