Tyrosine kinase inhibitors. VIII: An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor
- Author
- BRIDGES, A. J1 ; HAIRONG ZHOU1 ; CODY, D. R1 ; REWCASTLE, G. W; MCMICHAEL, A1 ; SHOWALTER, H. D. H1 ; FRY, D. W1 ; KRAKER, A. J1 ; DENNY, W. A
[1] Warner-Lambert Co., Parke-Davis Pharmaceutical Research, Ann Arbor MI 48106-1047, United States - Source
Journal of medicinal chemistry (Print). 1996, Vol 39, Num 1, pp 267-276 ; ref : 32 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Amine secondaire Anticancéreux Carcinome Cellule tumorale Composé bicyclique Facteur croissance épiderme Homme Hétérocycle azote In vitro Inhibiteur enzyme Protein-tyrosine kinase Quinazoline dérivé Relation structure activité Récepteur biologique Synthèse chimique Aniline dérivé PD 153035 Quinazoline(4-[3-bromoanilino]-6,7-diéthoxy) Quinazoline(4-anilino) Enzyme Transferases
- Keyword (en)
- Secondary amine Antineoplastic agent Carcinoma Tumor cell Bicyclic compound Epidermal growth factor Human Nitrogen heterocycle In vitro Enzyme inhibitor Protein-tyrosine kinase Quinazoline derivatives Structure activity relation Biological receptor Chemical synthesis Enzyme Transferases
- Keyword (es)
- Amina secundaria Anticanceroso Carcinoma Célula tumoral Compuesto bicíclico Factor crecimiento epidermi Hombre Heterociclo nitrógeno In vitro Inhibidor enzima Protein-tyrosine kinase Relación estructura actividad Receptor biológico Síntesis química Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 2965198
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm9503613 
https://dx.doi.org/10.1021/jm9503613
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