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Practical total synthesis of (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol, the antitumorial and immunostimulatory α-galactosylceramide, KRN7000

Author
MORITA, M1 ; SAWA, E1 ; YAMAJI, K1 ; SAKAI, T1 ; NATORI, T1 ; KOEZUKA, Y1 ; FUKUSHIMA, H1 ; AKIMOTO, K1
[1] Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd. 3 Miyahara-cho, Takasaki-shi, Gunma 370-12, Japan
Source

Bioscience, biotechnology, and biochemistry. 1996, Vol 60, Num 2, pp 288-292 ; ref : 23 ref

ISSN
0916-8451
Scientific domain
Biochemistry, molecular biology, biophysics; General biology; Biotechnology
Publisher
Japan Society for Bioscience Biotechnology and Agrochemistry, Tokyo
Publication country
Japan
Document type
Article
Language
English
Keyword (fr)
Aldose Anticancéreux Céramide Glycolipide Glycoside Immunostimulant Sphingoglycolipide Synthèse chimique Synthèse totale Agélasphine analogue Galactopyranosyle(tétra-O-benzyl) bromure Hexacosanoïque acide KRN 7000 Lyxose Octadécane-3,4-diol(1-α-D-galactopyranosyloxy-2-hexacosanoylamino) Phosphonium(tridécyl triphényl) bromure
Keyword (en)
Aldose Antineoplastic agent Ceramide Glycolipid Glycoside Immunostimulant agent Sphingoglycolipid Chemical synthesis Total synthesis
Keyword (es)
Aldosa Anticanceroso Cerámida Glicolípido Glicósido Inmunoestimulante Esfingoglicolípido Síntesis química Síntesis total
Classification
Pascal
001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C09 Lipids

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Organic chemistry Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
3046199

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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