Potent inhibitors of acyl-CoA:cholesterol acyltransferase . II. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides
- Author
- KATAOKA, K.-I1 ; SHIOTA, T1 ; YAMAGUCHI, H2 ; TAKEYASU, T1 ; MINOSHIMA, T; WATANABE, K; TANAKA, H1 ; MOCHIZUKI, T1 ; TANEDA, K1 ; OTA, M1 ; TANABE, H1
[1] Teijin Institute for Bio-Medical Research, 4-3-2 Asahigaoka, Hino, Tokyo 191, Japan
[2] Teijin Institute for Bio-Medical Research, 4-3-2 Asahigaoka, Hino, Tokyo 191, Japan - Source
Journal of medicinal chemistry (Print). 1996, Vol 39, Num 6, pp 1262-1270 ; ref : 14 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Benzofurane dérivé Benzène dérivé Biodisponibilité Carboxamide Chien Chimiothérapie Cholestérol Composé aliphatique Composé aromatique Composé bicyclique Hypercholestérolémie Hypolipémiant Hétérocycle oxygène In vitro In vivo Inhibiteur enzyme Lapin Pathologie expérimentale Pharmacocinétique Rat Relation structure activité Sterol O-acyltransferase Synthèse chimique Traitement Voie orale Benzamide dérivé Laurique acide(2,2-diméthyl) [2,3-dihydro-5-diméthylamino-2,2,4,6-tétraméthyl-7-benzofuryl]amide TEI 6620 Acyltransferases Carnivora Enzyme Fissipedia Lagomorpha Mammalia Rodentia Transferases Trouble métabolisme Vertebrata
- Keyword (en)
- Animal Benzofuran derivatives Benzene derivatives Bioavailability Carboxamide Dog Chemotherapy Cholesterol Aliphatic compound Aromatic compound Bicyclic compound Hypercholesterolemia Antilipemic agent Oxygen heterocycle In vitro In vivo Enzyme inhibitor Rabbit Experimental disease Pharmacokinetics Rat Structure activity relation Sterol O-acyltransferase Chemical synthesis Treatment Oral administration Acyltransferases Carnivora Enzyme Fissipedia Lagomorpha Mammalia Rodentia Transferases Metabolic disorder Vertebrata
- Keyword (es)
- Animal Benceno derivado Biodisponibilidad Carboxamida Perro Quimioterapia Colesterol Compuesto alifático Compuesto aromático Compuesto bicíclico Hipercolesterolemia Hipolipemiante Heterociclo oxígeno In vitro In vivo Inhibidor enzima Conejo Patología experimental Farmacocinética Rata Relación estructura actividad Sterol O-acyltransferase Síntesis química Tratamiento Vía oral Acyltransferases Carnivora Enzima Fissipedia Lagomorpha Mammalia Rodentia Transferases Trastorno metabolismo Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3061946
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm950828+ 
https://dx.doi.org/10.1021/jm950828+
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