Preparation and antirheumatic activity of optically active 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298)
- Author
- KAMEO, K1 ; TAKESHITA, K1 ; YASUDA, Y1 ; MATSUMOTO, K1 ; TOMISAWA, K1
[1] Research Centre, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Ohmiya, Saitama 330, United States - Source
Chemical and pharmaceutical bulletin. 1996, Vol 44, Num 3, pp 602-604 ; ref : 11 ref
- CODEN
- CPBTAL
- ISSN
- 0009-2363
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Maruzen, Tokyo
- Publication country
- Japan
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Activité optique Adjuvant Animal Antiinflammatoire Antirhumatismal Arthrite Chimiothérapie Configuration absolue Dédoublement optique Immunodépression In vitro In vivo Mécanisme action Pathologie expérimentale Rat Souris Synthèse chimique Traitement Benzènebutyrique acide(β-acétylthiométhyl-4-méthyl-γ-oxo) KE 298 Mammalia Rhumatisme inflammatoire Rodentia Système ostéoarticulaire pathologie Vertebrata
- Keyword (en)
- Biological activity Optical activity Adjuvant Animal Antiinflammatory agent Antirheumatic agent Arthritis Chemotherapy Absolute configuration Optical resolution Immunosuppression In vitro In vivo Mechanism of action Experimental disease Rat Mouse Chemical synthesis Treatment Mammalia Inflammatory joint disease Rodentia Diseases of the osteoarticular system Vertebrata
- Keyword (es)
- Actividad biológica Actividad óptica Coadyuvante Animal Antiinflamatorio Antireumático Artritis Quimioterapia Configuración absoluta Desdoblamiento óptico Inmunodepresión In vitro In vivo Mecanismo acción Patología experimental Rata Ratón Síntesis química Tratamiento Mammalia Reumatismo inflamatorio Rodentia Sistema osteoarticular patología Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3067338
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1248/cpb.44.602 
https://dx.doi.org/10.1248/cpb.44.602
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