Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors
- Author
- NUGIEL, D. A1 ; JACOBS, K1 ; BACHELER, L. T2 ; RAYNER, M. M2 ; SEITZ, S. P2 ; WORLEY, T1 ; PATEL, M1 ; KALTENBACH, R. F1 ; MEYER, D. T1 ; JADHAV, P. K1 ; DE LUCCA, G. V1 ; SMYSER, T. E2 ; KLABE, R. M2
[1] The Dupong Merck Pharmaceutical Company, Box 80500, Wilmington, Delaware 19880-0500, United States
[2] The Dupong Merck Pharmaceutical Company, Box 80500, Wilmington, Delaware 19880-0500, United States - Source
Journal of medicinal chemistry (Print). 1996, Vol 39, Num 11, pp 2156-2169 ; ref : 35 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antiviral Benzène dérivé Cycle 7 chaînons Cyclopropane dérivé Glycol Hétérocycle azote In vitro Inhibiteur enzyme Modèle moléculaire Modélisation Proteinases Relation structure activité Site actif Site fixation Synthèse chimique Urées Virus HIV1 1,3-Diazépan-2-one dérivé DMP 323 Enzyme Hydrolases Lentivirinae Retroviridae Virus immunodéficience humaine Virus
- Keyword (en)
- Antiviral Benzene derivatives Seven membered ring Cyclopropane derivatives Glycol Nitrogen heterocycle In vitro Enzyme inhibitor Molecular model Modeling Proteinases Structure activity relation Active site Binding site Chemical synthesis Ureas HIV-1 virus Enzyme Hydrolases Lentivirinae Retroviridae Human immunodeficiency virus Virus
- Keyword (es)
- Antiviral Benceno derivado Ciclo 7 eslabones Ciclopropano derivado Glicol Heterociclo nitrógeno In vitro Inhibidor enzima Modelo molecular Modelización Proteinases Relación estructura actividad Lugar activo Sitio fijación Síntesis química Ureas HIV-1 virus Enzima Hydrolases Lentivirinae Retroviridae Human immunodeficiency virus Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3107211
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm960083n 
https://dx.doi.org/10.1021/jm960083n
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