Preclinical toxicity evaluation of tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, in Sprague-Dawley rats and beagle dogs
- Author
- KNIGHT, E. V1 ; KIMBALL, J. P1 ; SZOT, R. J2 ; KEENAN, C. M1 ; SMITH, I. L1 ; WONG, F. A1 ; BARRETT, D. S1 ; DEMPSTER, A. M1 ; LIEUALLEN, W. G1 ; PANIGRAPHI, D2 ; POWERS, W. J2
[1] Department of Drug Safety Evaluation, The R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869-0602, United States
[2] Department of Drug Safety Evaluation, The R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869-0602, United States - Source
Fundamental and applied toxicology (Print). 1996, Vol 33, Num 1, pp 38-48 ; ref : 26 ref
- CODEN
- FAATDF
- ISSN
- 0272-0590
- Scientific domain
- Toxicology
- Publisher
- Academic Press, Boston, MA
/
Academic Press, New York, NY
/
Academic Press, San Diego, CA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antiinflammatoire Appareil digestif pathologie Arachidonate 5-lipoxygenase Chien Cinétique Dose répétée Inhibiteur enzyme Innocuité Métabolisme Prostaglandin-endoperoxide synthase Rat Toxicité Toxicocinétique Tépoxaline Ulcère Voie orale Carnivora Enzyme Fissipedia Mammalia Oxidoreductases Rodentia Vertebrata
- Keyword (en)
- Animal Antiinflammatory agent Digestive diseases Arachidonate 5-lipoxygenase Dog Kinetics Multiple dose Enzyme inhibitor Harmlessness Metabolism Prostaglandin-endoperoxide synthase Rat Toxicity Toxicokinetics Ulcer Oral administration Carnivora Enzyme Fissipedia Mammalia Oxidoreductases Rodentia Vertebrata
- Keyword (es)
- Animal Antiinflamatorio Aparato digestivo patología Arachidonate 5-lipoxygenase Perro Cinética Dosis múltiple Inhibidor enzima Inocuidad Metabolismo Prostaglandin-endoperoxide synthase Rata Toxicidad Toxicocinética Ulcera Vía oral Carnivora Enzima Fissipedia Mammalia Oxidoreductases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U10 Miscellaneous (drug allergy, mutagens, teratogens...)
- Discipline
- Drugs toxicity and drug intoxications Toxicology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3207698
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1006/faat.1996.0141 
https://dx.doi.org/10.1006/faat.1996.0141
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