Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase
- Author
- RIVORY, L. P1 ; BOWLES, M. R1 ; ROBERT, J2 ; POND, S. M1
[1] University of Queensland Department of Medicine, Princess Hospital, Brisbane, Queensland, 4102, Australia
[2] Institut Bergonié, Bordeaux 33076, France - Source
Biochemical pharmacology. 1996, Vol 52, Num 7, pp 1103-1111 ; ref : 15 ref
- CODEN
- BCPCA6
- ISSN
- 0006-2952
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs; Physiology, morphology
- Publisher
- Elsevier Science, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activation métabolique Anticancéreux Carboxylesterase Cinétique DNA topoisomerase Foie Homme In vitro Inhibiteur enzyme Irinotécan Mécanisme action Métabolisme CPT 11 SN 38 Carboxylic ester hydrolases Enzyme Esterases Hydrolases Isomerases
- Keyword (en)
- Metabolic activation Antineoplastic agent Carboxylesterase Kinetics DNA topoisomerase Liver Human In vitro Enzyme inhibitor Mechanism of action Metabolism Carboxylic ester hydrolases Enzyme Esterases Hydrolases Isomerases
- Keyword (es)
- Activación metabólica Anticanceroso Carboxylesterase Cinética DNA topoisomerase Hígado Hombre In vitro Inhibidor enzima Mecanismo acción Metabolismo Carboxylic ester hydrolases Enzima Esterases Hydrolases Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3260275
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/0006-2952(96)00457-1 
https://dx.doi.org/10.1016/0006-2952(96)00457-1
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