Importance of parallel vectors and hydrophobic collapse of the aligned aromatic rings : discovery of a potent substance P antagonist
- Author
- DESAI, M. C; VINCENT, L. A; RIZZI, J. P
Pfizer Inc., cent. res. div., Groton CT 06340, United States - Source
Journal of medicinal chemistry (Print). 1994, Vol 37, Num 25, pp 4263-4266 ; ref : 16 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antagoniste Composé bicyclique Conformation Encombrement stérique Hétérocycle azote Modèle moléculaire Modélisation Racémique Relation structure activité Récepteur tachykinine NK1 Spirane Substance P Synthèse chimique 1,8-Diazaspiro[5.5]undécane(3-[2-méthoxyphényl]-7-phényl) CP 99 994
- Keyword (en)
- Antagonist Bicyclic compound Conformation Steric hindrance Nitrogen heterocycle Molecular model Modeling Racemate Structure activity relation NK1 receptor Spiran Substance P Chemical synthesis
- Keyword (es)
- Antagonista Compuesto bicíclico Conformación Embarazo estérico Heterociclo nitrógeno Modelo molecular Modelización Racémico Relación estructura actividad Receptor taquikinina NK1 Espirano Substancia P Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09G Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3356842
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00051a001 
https://dx.doi.org/10.1021/jm00051a001
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