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Synthesis of two distamycin analogues and their binding mode to d(CGCAAATTTGCG)2 in the 2:1 solution complexes as determined by two-dimensional 1H-NMR

Author
ANIMATI, F1 ; ARCAMONE, F. M1 ; CONTE, M. R2 ; FELICETTI, P1 ; GALEONE, A2 ; LOMBARDI, P1 ; MAYOL, L2 ; PALOMA, L. G2 ; ROSSI, C1
[1] Menarini ric. Sud, dip. chimica, 00040 Pomezia, Italy
[2] Univ. Napoli Federico II, dip. chimica sostanze naturali, 80131 Napoli, Italy
Source

Journal of medicinal chemistry (Print). 1995, Vol 38, Num 7, pp 1140-1149 ; ref : 28 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Affinité Amidine Anticancéreux Antiviral DNA Effet Overhauser Fixation biologique Interaction moléculaire Modèle moléculaire Modélisation Oligodésoxyribonucléotide Pyrrole dérivé Spectrométrie 2 dimensions Synthèse chimique Tétramère Distamycine Propionimidique acide3-[4-(4-[4-(4-carbamoyl-1-méthylpyrrole-2-carbonylamino)1-méthylpyrrole-2-carbonylamino]-1-méthylpyrrole-2-carbonylamino)-1-méthylpyrrole-2-carbonylamino] amide Propionimidique acide3-[4-(4-[4-(4-carbonylamino-1-méthylpyrrole-2-carbonylamino)1-méthylpyrrole-2-carbonylamino]-1-méthylpyrrole-2-carbonylamino)-1-méthylpyrrole-2-carbonylamino] amide Sillon mineur Stillamycine
Keyword (en)
Affinity Amidine Antineoplastic agent Antiviral DNA Overhauser effect Biological fixation Molecular interaction Molecular model Modeling Oligodeoxyribonucleotide Pyrrole derivatives Two dimension spectrometry Chemical synthesis Tetramer Minor groove
Keyword (es)
Afinidad Amidina Anticanceroso Antiviral DNA Efecto Overhauser Fijación biológica Interacción molecular Modelo molecular Modelización Oligodesoxirribonucleótido Pirrol derivado Espectrometría bidimensional Síntesis química Tetrámero
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
3493112

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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