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Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues

Author
LESCHKE, C1 ; SIGURD ELZ1 ; GARBARG, M2 ; SCHUNACK, W1
[1] Freie Univ. Berlin, inst. pharmacology, 14195 Berlin, Germany
[2] INSERM, cent. Paul Broca, unité neurobiologie pharmacologie, 75014 Paris, France
Source

Journal of medicinal chemistry (Print). 1995, Vol 38, Num 8, pp 1287-1294 ; ref : 50 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Agoniste Amine primaire Animal Cobaye Fixation biologique Histamine Hétérocycle azote Imidazole dérivé In vitro In vivo Intestin Relation structure activité Récepteur histaminergique H1 Souris Synthèse chimique Système nerveux central Sélectivité Vaisseau sanguin Imidazole(4-[2-aminoéthyl]-2-aryl) Imidazole(4-[2-aminoéthyl]-2-hétéryl) Mammalia Rodentia Vertebrata
Keyword (en)
Agonist Primary amine Animal Guinea pig Biological fixation Histamine Nitrogen heterocycle Imidazole derivatives In vitro In vivo Gut Structure activity relation H1 receptor Mouse Chemical synthesis Central nervous system Selectivity Blood vessel Mammalia Rodentia Vertebrata
Keyword (es)
Agonista Amina primaria Animal Cobayo Fijación biológica Histamina Heterociclo nitrógeno Imidazol derivado In vitro In vivo Intestino Relación estructura actividad Receptor histaminérgico H1 Ratón Síntesis química Sistema nervioso central Selectividad Vaso sanguíneo Mammalia Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09G Miscellaneous

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
3517507

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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