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Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase

Author
VELAZQUEZ, S1 ; ALVAREZ, R1 ; SAN-FELIX, A1 ; JIMENO, M. L1 ; DE CLERCQ, E; BALZARINI, J; CAMARASA, M. J1
[1] CSIC, inst. química médica, 28006 Madrid, Spain
Source

Journal of medicinal chemistry (Print). 1995, Vol 38, Num 10, pp 1641-1649 ; ref : 41 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Antiviral Composé aliphatique Didésoxynucléoside Dimère In vitro Inhibiteur enzyme Lignée cellulaire établie Pyrimidine nucléoside RNA-directed DNA polymerase Relation structure activité Spirane Synthèse chimique Virus HIV1 Zidovudine Bras espaceur Composé non nucléoside Hétéromère Lignée CEM/O Lignée CEM/TK Spiro[1,2-oxathiole-5:3p-thymidine](4-amino-3p-désoxy-2p,5p-di-O-t-butyldiméthylsilyl)-2,2-dioxyde Thymidine(1-[(2-hydroxyéthoxy)méthyl]-6-phénylthio) Enzyme Lentivirinae Nucleotidyltransferases Retroviridae Transferases Virus immunodéficience humaine Virus
Keyword (en)
Antiviral Aliphatic compound Dideoxynucleoside Dimer In vitro Enzyme inhibitor Established cell line Pyrimidine nucleoside RNA-directed DNA polymerase Structure activity relation Spiran Chemical synthesis HIV-1 virus Spacer arm Nonnucleoside compound Enzyme Lentivirinae Nucleotidyltransferases Retroviridae Transferases Human immunodeficiency virus Virus
Keyword (es)
Antiviral Compuesto alifático Didesoxinucleósido Dímero In vitro Inhibidor enzima Línea celular establecida Pirimidina nucleósido RNA-directed DNA polymerase Relación estructura actividad Espirano Síntesis química HIV-1 virus Enzima Lentivirinae Nucleotidyltransferases Retroviridae Transferases Human immunodeficiency virus Virus
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
3535877

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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