Hyperproinsulineamia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
- Author
- NAGGERT, J. K1 ; FRICKER, L. D; VARLAMOV, O; NISHINA, P. M1 ; ROUILLE, Y; STEINER, D. F; CARROLL, R. J; PAIGEN, B. J1 ; LEITER, E. H1
[1] Jackson lab., Bar Habor ME 04609, United States - Source
Nature genetics. 1995, Vol 10, Num 2, pp 135-142 ; ref : 41 ref
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité enzymatique Carboxypeptidase H Carte génétique Chromosome 8 Diabète Gène Hyperglycémie Hyperinsulinémie Maturation moléculaire Modèle animal Mutation Obésité Proinsuline Souris Endocrinopathie Enzyme Hydrolases Mammalia Metallocarboxypeptidases Métabolisme pathologie Prohormone Proteinases Protéine Rodentia Trouble nutrition Vertebrata
- Keyword (en)
- Enzymatic activity Carboxypeptidase H Genetic mapping Chromosome 8 Diabetes mellitus Gene Hyperglycemia Hyperinsulinemia Molecular processing Animal model Mutation Obesity Proinsulin Mouse Endocrinopathy Enzyme Hydrolases Mammalia Metallocarboxypeptidases Metabolic diseases Prohormone Proteinases Proteins Rodentia Nutrition disorder Vertebrata
- Keyword (es)
- Actividad enzimática Carboxypeptidase H Mapa genético Cromosoma 8 Diabetes Gen Hiperglicemia Hiperinsulinemia Maduración molecular Modelo animal Mutación Obesidad Proinsulina Ratón Endocrinopatía Enzima Hydrolases Mammalia Metallocarboxypeptidases Metabolismo patología Prohormona Proteinases Proteína Rodentia Trastorno nutricíon Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution / 002A07C Classical genetics, quantitative genetics, hybrids / 002A07C01 Animals / 002A07C01B Vertebrata
- Discipline
- Eukaryotes genetics. Biological and molecular evolution
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3573086
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng0695-135 
https://dx.doi.org/10.1038/ng0695-135
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