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Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides

Author
VERHEGGEN, I1 ; VAN AERSCHOT, A1 ; HERDEWIJN, P; VAN MEERVELT, L; ROZENSKI, J1 ; WIEBE, L; SNOECK, R1 ; ANDREI, G1 ; BALZARINI, J1 ; CLAES, P1 ; DE CLERCQ, E1
[1] Katholieke univ. Leuven, Rega inst. medical res., lab. pharmaceutical chemistry and lab. virology chemotherapy, 3000 Leuven, Belgium
Source

Journal of medicinal chemistry (Print). 1995, Vol 38, Num 5, pp 826-835 ; ref : 28 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Alditol Antiviral Conformation Diffraction RX Herpesvirus hominis 1 Herpesvirus hominis 2 In vitro Lignée cellulaire établie Purine nucléoside Pyrimidine nucléoside Relation structure activité Synthèse chimique Hexitol(1,5-anhydro-3-désoxy-4,6-O-éthylidène) Uracile(1-[1,5-anhydro-2,3-didésoxy-D-arabino-hexitol-2-yl]-5-iodo) Uracile(1-[1,5-anhydro-2,3-didésoxy-D-arabino-hexitol-2-yl]-5-éthyl) Alphaherpesvirinae Herpesviridae Virus
Keyword (en)
Alditol Antiviral Conformation X ray diffraction Herpesvirus hominis 1 Herpesvirus hominis 2 In vitro Established cell line Purine nucleoside Pyrimidine nucleoside Structure activity relation Chemical synthesis Alphaherpesvirinae Herpesviridae Virus
Keyword (es)
Alditol Antiviral Conformación Difracción RX Herpesvirus hominis 1 Herpesvirus hominis 2 In vitro Línea celular establecida Purina nucleósido Pirimidina nucleósido Relación estructura actividad Síntesis química Alphaherpesvirinae Herpesviridae Virus
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
3615387

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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