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Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase

Author
VAN CALENBERGH, S1 ; VERLINDE, C. L. M. J; SOENENS, J1 ; DE BRUYN, A; CALLENS, M; BLATON, N. M; PEETERS, O. M; ROZENSKI, J; HOL, W. G. J; HERDEWIJN, P1
[1] Univ. Ghent, lab. medicinal chemistry, 9000 Ghent, Belgium
Source

Journal of medicinal chemistry (Print). 1995, Vol 38, Num 19, pp 3838-3849 ; ref : 21 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Aminocyclitol Aminoglycoside Antiparasitaire Antiprotozoaire Glyceraldehyde-3-phosphate dehydrogenase (NADP+) Homme In vitro Inhibiteur enzyme Purine nucléoside Relation structure activité Synthèse chimique Trypanosoma brucei Adénosine(2p-désoxy-2p-[3-méthoxybenzamido]) Enzyme Oxidoreductases Protozoa Rhizoflagellata
Keyword (en)
Aminocyclitols Aminoglycoside Parasiticid Antiprotozoal agent Glyceraldehyde-3-phosphate dehydrogenase (NADP+) Human In vitro Enzyme inhibitor Purine nucleoside Structure activity relation Chemical synthesis Trypanosoma brucei Enzyme Oxidoreductases Protozoa Rhizoflagellata
Keyword (es)
Aminociclitol Aminoglicósido Antiparasitario Antiprotozoario Glyceraldehyde-3-phosphate dehydrogenase (NADP+) Hombre In vitro Inhibidor enzima Purina nucleósido Relación estructura actividad Síntesis química Trypanosoma brucei Enzima Oxidoreductases Protozoa Rhizoflagellata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
3668292

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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