Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand
- Author
- ROSEN, T1 ; SEEGER, T. F1 ; ROTH, R. W; MCLEAN, S1 ; DESAI, M. C1 ; GUARINO, K. J1 ; BRYCE, D1 ; PRATT, K1 ; HEYM, J1 ; CHALABI, P. M; WINDELS, J. H
[1] Pfizer Central Research, dep. medicinal chemistry, Groton CT 06340, United States - Source
Journal of medicinal chemistry (Print). 1993, Vol 36, Num 21, pp 3197-3201 ; ref : 13 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Antagoniste Autoradiographie Cerveau Composé benzénique Composé marqué Composé saturé Cycle 6 chaînons Distribution Hétérocycle azote In vitro Racémique Récepteur biologique Substance P Tritium Pipéridine(3-[2-méthoxybenzylamino]-2-phényl)
- Keyword (en)
- Biological activity Antagonist Autoradiography Brain (invertebrata) Benzenic compound Labelled compound Saturated compound Six membered ring Distribution Nitrogen heterocycle In vitro Racemate Biological receptor Substance P Tritium
- Keyword (es)
- Actividad biológica Antagonista Autorradiografía Cerebro Compuesto bencénico Compuesto marcado Compuesto saturado Ciclo 6 eslabones Distribución Heterociclo nitrógeno In vitro Racémico Receptor biológico Substancia P Tritio
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06B Heterocyclic compounds with only one n hetero atom and condensed derivatives
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3804326
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00073a022 
https://dx.doi.org/10.1021/jm00073a022
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