Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reducatases and as potential antipneumocystis, antitoxoplasma, and antitumor agents
- Author
- ALEEM GANGJEE1 ; JUFANG SHI1 ; QUEENER, S. F; BARROWS, L. R; KISLIUK, R. L
[1] Duquesne univ., graduate school pharmaceutical sci., div. medicinal chemistry, Pittsburgh PA 15282, United States - Source
Journal of medicinal chemistry (Print). 1993, Vol 36, Num 22, pp 3437-3443 ; ref : 30 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Amination Anticancéreux Composé bicyclique Dihydrofolate reductase Guanidines Hétérocycle azote Inhibiteur enzyme Réduction chimique Pyrido[2,3-d]pyrimidine(6-anilinométhyl-2,4-diamino-5-méthyl) Pyrido[2,3-d]pyrimidine-6-carbonitrile(2,4-diamino-5-méthyl) Enzyme Oxidoreductases
- Keyword (en)
- Biological activity Amination Antineoplastic agent Bicyclic compound Dihydrofolate reductase Guanidines Nitrogen heterocycle Enzyme inhibitor Chemical reduction Enzyme Oxidoreductases
- Keyword (es)
- Actividad biológica Aminación Anticanceroso Compuesto bicíclico Dihydrofolate reductase Guanidinas Heterociclo nitrógeno Inhibidor enzima Reducción química Enzima Oxidoreductases
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06C Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3817177
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00074a026 
https://dx.doi.org/10.1021/jm00074a026
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