P1 aspartate-based peptide α-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1β-converting enzyme
- Author
- DOLLE, R. E; HOYER, D; PRASAD, C. V. C; SCHMIDT, S. J; HELASZEK, C. T; MILLER, R. E; ATOR, M. A
Sterling Winthrop Pharmaceuticals, dep. medicinal chemistry, Collegeville PA 19426, United States - Source
Journal of medicinal chemistry (Print). 1994, Vol 37, Num 5, pp 563-564 ; ref : 14 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Cathepsin B Cétone Inhibiteur enzyme Peptide Aspartique acide(N-benzyloxycarbonyl) ester 4-[t-butyle] Valérique acide(3-[(benzyloxycarbonyl)valyl-alanylamino]-5-[2,6-dichlorobenzoyloxy]-4-oxo) Valérique acide(3-[(benzyloxycarbonyl)valylamino]-5-[2,6-dichlorobenzoyloxy]-4-oxo) Valérique acide(3-amino-5-[2,6-dichlorobenzoyloxy]-4-oxo) Chlore Composé organique Cysteine endopeptidases Enzyme Hydrolases Proteinases
- Keyword (en)
- Biological activity Cathepsin B Ketone Enzyme inhibitor Peptides Chlorine Organic compounds Cysteine endopeptidases Enzyme Hydrolases Proteinases
- Keyword (es)
- Actividad biológica Cathepsin B Cetona Inhibidor enzima Péptido Cloro Compuesto orgánico Cysteine endopeptidases Enzima Hydrolases Proteinases
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C08 Peptides
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 3968023
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00031a003 
https://dx.doi.org/10.1021/jm00031a003
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