Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides : identification of 4[[5-((2R)-2-methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methylindol-3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a potent, orally active antagonist of leukotrienes D4 and E4
- Author
- JACOBS, R. T; BERNSTEIN, P. R; CRONK, L. A; VACEK, E. P; NEWCOMB, L. F; AHARONY, D; BUCKNER, C. K; KUSNER, E. J
ZENECA Inc., dep. medicinal chemistry, ZENECA pharmaceuticals group, Wilmington DE 19897, United States - Source
Journal of medicinal chemistry (Print). 1994, Vol 37, Num 9, pp 1282-1297 ; ref : 41 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antagoniste Carboxamide Composé aromatique Composé bicyclique Enantiosélectivité Hétérocycle azote Imide In vitro Indole dérivé Leucotriène B4 Leucotriène E4 Relation structure activité Sulfonamide Benzamide dérivé Butylamine(2-méthyl-4,4,4-trifluoro) Indole-5-carboxylique acide(3-[2-méthoxy-4-([o-toluènesulfonyl]carbamoyl)benzyl]-1-méthyl)[2-méthyl-4,4,4-trifluoro]butylamide Indole-6-carboxylique acide Fluor Composé organique
- Keyword (en)
- Antagonist Carboxamide Aromatic compound Bicyclic compound Enantioselectivity Nitrogen heterocycle Imide In vitro Indole derivatives Leukotriene B4 Leukotriene E4 Structure activity relation Sulfonamide Fluorine Organic compounds
- Keyword (es)
- Antagonista Carboxamida Compuesto aromático Compuesto bicíclico Enantioselectividad Heterociclo nitrógeno Imida In vitro Indol derivado Leucotrieno B4 Leucotrieno E4 Relación estructura actividad Sulfonamida Fluor Compuesto orgánico
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06B Heterocyclic compounds with only one n hetero atom and condensed derivatives
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 4066062
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00035a008 
https://dx.doi.org/10.1021/jm00035a008
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