Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (Docetaxel)
- Author
- OJIMA, I1 ; DUCLOS, O1 ; ZUCCO, M1 ; BISSERY, M.-C; COMBEAU, C; VRIGNAUD, P; RIOU, J. F; LAVELLE, F
[1] State univ. New York Stony Brook, dep. chemistry, Stony Brook NY 11794-3400, United States - Source
Journal of medicinal chemistry (Print). 1994, Vol 37, Num 16, pp 2602-2608 ; ref : 35 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acylate Aminoacide Aminoalcool Animal Anticancéreux Composé tétracyclique Diterpène Hétérocycle oxygène In vitro In vivo Leucémie P388 Lignée cellulaire Mélanome B16 Polyol Relation structure activité Souris Voie intraveineuse Docétaxel(bis[déphényl]-dicyclohexyl) Docétaxel(cyclohexyl-déphényl) Paclitaxel(2-cyclohexyl-2-déphényl) Taxane dérivé Mammalia Rodentia Vertebrata
- Keyword (en)
- Acylate Aminoacid Aminoalcohol Animal Antineoplastic agent Tetracyclic compound Diterpene Oxygen heterocycle In vitro In vivo P388-Leukemia Cell line B16-Melanoma Polyol Structure activity relation Mouse Intravenous administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Acilato Aminoácido Aminoalcohol Animal Anticanceroso Compuesto tetracíclico Diterpeno Heterociclo oxígeno In vitro In vivo Leucemia P388 Línea celular Melanoma B16 Poliol Relación estructura actividad Ratón Vía intravenosa Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C05 Alicyclic compounds, terpenoids, prostaglandins, steroids / 001C03C05B Terpenoids
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 4179413
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00042a013 
https://dx.doi.org/10.1021/jm00042a013
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