Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues : agonists for the 5-HT1D receptor
- Author
- CASTRO, J. L; BAKER, R; GRAHAM, M. I; MATASSA, V. G; GUIBLIN, A. R; HOBBS, S. C; JENKINS, M. R; RUSSELL, M. G. N; BEER, M. S; STANTON, J. A; SCHOLEY, K; HARGREAVES, R. J
Merck Sharp & Dohme Research Laboratories, chemistry biochemistry dep., Harlow Essex CM20 2QR, United Kingdom - Source
Journal of medicinal chemistry (Print). 1994, Vol 37, Num 19, pp 3023-3032 ; ref : 33 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Agoniste Composé aromatique Composé bicyclique Cycle 5 chaînons Hétérocycle azote Hétérocycle soufre azote In vitro Indole dérivé Relation structure activité Récepteur sérotoninergique S1 Sulfamides Tryptamine dérivé Voie orale 2,1,3-Thiadiazolidine(1-[3-(2-[diméthylamino]éthyl)indol-5-ylméthyl]-3-méthyl)-2,2-dioxyde Récepteur sérotoninergique S1D
- Keyword (en)
- Agonist Aromatic compound Bicyclic compound Five membered ring Nitrogen heterocycle Sulfur nitrogen heterocycle In vitro Indole derivatives Structure activity relation S1 receptor Sulfanilamide derivatives Tryptamine derivatives Oral administration
- Keyword (es)
- Agonista Compuesto aromático Compuesto bicíclico Ciclo 5 eslabones Heterociclo nitrógeno Heterociclo azufre nitrógeno In vitro Indol derivado Relación estructura actividad Receptor serotoninérgico S1 Sulfamidas Vía oral
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06B Heterocyclic compounds with only one n hetero atom and condensed derivatives
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 4228059
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00045a006 
https://dx.doi.org/10.1021/jm00045a006
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