Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences
- Author
- SINGER, I. I1 ; KAWKA, D. W1 ; FORREST, M. J; KAZAZIS, D. M1 ; MING-FAN LAW; LENNY, A. B; MACINTYRE, D. E; MEURER, R; PADLAN, E. A; PANDYA, S1 ; SCHMIDT, J. A1 ; SEAMANS, T. C; DEMARTINO, J. A; SCOTT, S1 ; SILBERKLANG, M; WILLIAMSON, A. R; MARK, G. E; DAUGHERTY, B. L; ELLISTON, K. O; ALVES, K; BUSH, B. L; CAMERON, P. M; CUCA, G. C; DAVIES, P
[1] Merck Research Laboratories, dep. biochemical molecular pathology, Rahway NJ 07065, United States - Source
The Journal of immunology (1950). 1993, Vol 150, Num 7, pp 2844-2857 ; ref : 68 ref
- CODEN
- JOIMA3
- ISSN
- 0022-1767
- Scientific domain
- Biochemistry, molecular biology, biophysics; Immunology, immunopathology, allergology
- Publisher
- American Association of Immunologists, Bethesda, MD
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticorps monoclonal Greffage Homme Immunogénicité Mutation Réaction antigène anticorps Région variable Souris Séquence nucléotide Antigène CD18 Région hypervariable Segment V Mammalia Rodentia Vertebrata
- Keyword (en)
- Monoclonal antibody Grafting Human Immunogenicity Mutation Antigen antibody reaction Variable region Mouse Nucleotide sequence Mammalia Rodentia Vertebrata
- Keyword (es)
- Anticuerpo monoclonal Injerto Hombre Inmunogenicidad Mutación Reacción antígeno anticuerpo Región variable Ratón Secuencia nucleótido Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A06 Fundamental immunology / 002A06B Molecular immunology / 002A06B03 Antibodies, immunoglobulins / 002A06B03D Monoclonal antibodies
- Discipline
- Fundamental immunology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 4734556
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.4049/jimmunol.150.7.2844 
https://dx.doi.org/10.4049/jimmunol.150.7.2844
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