A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps
- Author
- GROS, P1 ; DHIR, R; CROOP, J; TALBOT, F
[1] McGill univ., dep. biochemistry, Montreal PQ H3G 1Y6, Canada - Source
Proceedings of the National Academy of Sciences of the United States of America. 1991, Vol 88, Num 16, pp 7289-7293 ; ref : 75 ref
- CODEN
- PNASA6
- ISSN
- 0027-8424
- Scientific domain
- Multidisciplinary
- Publisher
- National Academy of Sciences of the United States of America, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Glycoprotéine Mutagenèse dirigée Médicament Protéine membranaire Relation structure activité Résistance Souris Spécificité substrat Gène mdr1 Gène mdr3 Mammalia Rodentia Vertebrata
- Keyword (en)
- Glycoproteins Site directed mutagenesis Drug Membrane protein Structure activity relation Resistance Mouse Substrate specificity Mammalia Rodentia Vertebrata
- Keyword (es)
- Glicoproteina Mutagénesis dirigida Medicamento Proteína membranar Relación estructura actividad Resistencia Ratón Especificidad sustrato Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02D Proteins / 002A02D06 Glycoproteins
- Discipline
- Analytical, structural and metabolic biochemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 4975398
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1073/pnas.88.16.7289 
https://dx.doi.org/10.1073/pnas.88.16.7289
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