Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid
- Author
- O'DWYER, P. J; LACRETA, F; NASH, S; TINSLEY, P. W; SCHILDER, R; CLAPPER, M. L; TEW, K. D; PANTING, L; COMIS, R. L; OZOLS, R. F
Fox Chase cancer cent., Philadelphia PA 19111, United States - Source
Cancer research (Baltimore). 1991, Vol 51, Num 22, pp 6059-6065 ; ref : 33 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Agent alkylant Anticancéreux Association médicamenteuse Chimiothérapie Efficacité traitement Essai clinique phase I Essai thérapeutique contrôlé Glutathione transferase Homme Inhibiteur enzyme Interaction médicamenteuse Pharmacocinétique Résistance Réversibilité Stade avancé Thiophosphoramidate organique Thiotepa Toxicité Traitement Tumeur maligne Voie intraveineuse Voie orale Étacrynique acide Aziridine dérivé Enzyme
- Keyword (en)
- Alkylating agent Antineoplastic agent Drug combination Chemotherapy Treatment efficiency Phase I trial Controlled therapeutic trial Glutathione transferase Human Enzyme inhibitor Drug interaction Pharmacokinetics Resistance Reversibility Advanced stage Organic thioamidophosphate Toxicity Treatment Malignant tumor Intravenous administration Oral administration Enzyme
- Keyword (es)
- Agente alquilante Anticanceroso Asociación medicamentosa Quimioterapia Eficacia tratamiento Ensayo clínico fase I Ensayo terapéutico controlado Glutathione transferase Hombre Inhibidor enzima Interacción medicamentosa Farmacocinética Resistencia Reversibilidad Estadio avanzado Tiofosforamidato orgánico Toxicidad Tratamiento Tumor maligno Vía intravenosa Vía oral Enzima
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 5036459
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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