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1,2,4-triazolo[4,3-a]pyrozine derivatives with human inhibitory activity. 2.1 synthesis, biological properties and molecular modeling of hydroxyethylene isostere derivatives

Author
BRADBURY, R. H; MAJOR, J. S; OLDHAM, A. A; RIVETT, J. E; ROBERTS, D. A; SLATER, A. M; TIMMS, D; WATERSON, D
ICI Pharmaceuticals, dep. chemistry biosci., Cheshire SK10 4TG, United Kingdom
Source

Journal of medicinal chemistry (Print). 1990, Vol 33, Num 9, pp 2335-2342 ; ref : 26 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Aminoalcool Carboxamide Composé cyclique Cycle 6 chaînons Hétérocycle azote angulaire Hétérocycle azote Inhibiteur enzyme Pseudopeptide Relation structure activité Renin Caproïque acide(5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl) butylamide Triazolo pyrazine dérivé Enzyme
Keyword (en)
Aminoalcohol Carboxamide Cyclic compound Six membered ring Angular nitrogen heterocycle Nitrogen heterocycle Enzyme inhibitor Pseudopeptide Structure activity relation Renin Enzyme
Keyword (es)
Aminoalcohol Carboxamida Compuesto cíclico Ciclo 6 eslabones Heterociclo nitrógeno angular Heterociclo nitrógeno Inhibidor enzima Seudopéptido Relación estructura actividad Renin Enzima
Classification
Pascal
001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06C Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings

Discipline
Organic chemistry
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
5233020

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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