Pharmacokinetics and pharmacodynamic modeling of direct suppression effects of methylprednisolone on serum cortisol and blood histamine in human subjects
- Author
- AH-NG KONG1 ; LUDWIG, E. A; SLAUGHTER, R. L; DISTEFANO, P. M; DEMASI, J; MIDDLETON, E. JR; JUSKO, W. J
[1] State univ. New York Buffalo, school pharmacy, dep. pharmaceutics, Buffalo NY 14260, United States - Source
Clinical pharmacology and therapeutics. 1989, Vol 46, Num 6, pp 616-628 ; ref : 49 ref
- CODEN
- CLPTAT
- ISSN
- 0009-9236
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Glucocorticoïde Histamine Homme Hormone stéroïde Hydrocortisone Immunodépression In vitro In vivo Modèle dynamique Modèle mathématique Méthylprednisolone Normal Pharmacocinétique Relation dose réponse Rythme circadien Récepteur biologique Sang Voie intraveineuse
- Keyword (en)
- Biological activity Glucocorticoid Histamine Human Steroid hormone Cortisol Immunosuppression In vitro In vivo Dynamic model Mathematical model Methylprednisolone Normal Pharmacokinetics Dose activity relation Circadian rhythm Biological receptor Blood Intravenous administration
- Keyword (es)
- Actividad biológica Glucocorticoide Histamina Hombre Hormona esteroide Hidrocortisona Inmunodepresión In vitro In vivo Modelo dinámico Modelo matemático Metilprednisolona Normal Farmacocinética Relación dosis respuesta Ritmo circadiano Receptor biológico Sangre Vía intravenosa
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 6716414
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/clpt.1989.196 
https://dx.doi.org/10.1038/clpt.1989.196
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