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Timolol prodrugs: synthesis, stability and lipophilicity of various alkyl, cycloalkyl and aromatic esters of timolol

Author
BUNDGAARD, H1 ; BUUR, A; SHIH-CHIEH CHANG; LEE, V. H. L
[1] Royal Danish school pharmacy, dep. pharmaceutical chemistry AD, Copenhagen 2100, Denmark
Source

International journal of pharmaceutics. 1988, Vol 46, Num 1-2, pp 77-88 ; ref : 22 ref

CODEN
IJPHDE
ISSN
0378-5173
Scientific domain
Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Keyword (fr)
Coefficient partage Ester Etude comparative Forme libération contrôlée Forme pharmaceutique Hydrolyse Oeil PH Promédicament Relation structure activité Relation structure propriété Spectrométrie RMN Stabilité Technologie pharmaceutique
Keyword (en)
Partition coefficient Ester Comparative study Controlled release form Dosage form Hydrolysis Eye PH Prodrug Structure activity relation Property structure relationship NMR spectrometry Stability Pharmaceutical technology
Keyword (es)
Coeficiente repartición Ester Estudio comparativo Forma liberación controlada Forma farmacéutica Hidrólisis Ojo PH Promedicamento Relación estructura actividad Relación estructura propiedad Espectrometría RMN Estabilidad Tecnología farmacéutica
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A01 Physicochemical properties. Structure-activity relationships

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
7187525

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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