Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin
- Author
- HEATHCOCK, C. H1 ; HADLEY, C. R; ROSEN, T; THEISEN, P. D; HECKER, S. J
[1] Univ. California, dep. chemistry, Berkeley CA 94720, United States - Source
Journal of medicinal chemistry (Print). 1987, Vol 30, Num 10, pp 1858-1873 ; ref : 40 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acylate Composé aliphatique Composé bicyclique Cycle 6 chaînons Cétol Diacide carboxylique Enantiomère(+) Enone Epimère Hydroxyacide Hydroxymethylglutaryl-CoA reductase Hétérocycle oxygène Inhibiteur enzyme Lactone Butyrique acide(méthyl-«2») ester [hydroxyméthyl-«8» méthyl-«7» tétrahydro-«5,6,7,8»] naphtyle-«1» Compactine analogue Compactine Glutarique acide(hydroxy-«3») ester [hexahydro méthyl-«2» méthyl-«2p» butyryloxy-«8»] naphtyl-«1»méthyle Mévinoline analogue Pyranne dérivé Œnanthique acide([hexahydro méthyl-2 méthyl-«2p» butyryloxy-«8» naphtyl-«1»]-«7» hydroxy-«3» oxo-«5»)
- Keyword (en)
- Acylate Aliphatic compound Bicyclic compound Six membered ring Ketol Dicarboxylic acid Enantiomer(+) Enone Epimer Hydroxyacid Hydroxymethylglutaryl-CoA reductase Oxygen heterocycle Enzyme inhibitor Lactone
- Keyword (es)
- Acilato Compuesto alifático Compuesto bicíclico Ciclo 6 eslabones Cetol Diácido carboxílico Enantiómero (+) Enona Epímero Hidroxiácido Hydroxymethylglutaryl-CoA reductase Heterociclo oxígeno Inhibidor enzima Lactona
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C06 Heterocyclic compounds / 001C03C06A Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives
- Discipline
- Organic chemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 7556493
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm00393a030 
https://dx.doi.org/10.1021/jm00393a030
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