Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor
- Author
- AUSTIN, Nigel E1 ; AVENELL, Kim Y1 ; SMITH, Alexander B1 ; STEMP, Geoffrey1 ; THEWLIS, Kevin M1 ; VONG, Antonio K. K1 ; WOOD, Martyn1 ; BOYFIELD, Izzy1 ; BRANCH, Clive L1 ; HADLEY, Michael S1 ; JEFFREY, Phillip1 ; JOHNSON, Christopher N1 ; MACDONALD, Gregor J1 ; NASH, David J1 ; RILEY, Graham J1
[1] SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom - Source
Bioorganic & medicinal chemistry letters (Print). 2000, Vol 10, Num 22, pp 2553-2555
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Animal Benzoazépine dérivé Carboxamide Composé aromatique Composé bicyclique Composé vinylique Fixation biologique Fluor Composé organique Hétérocycle azote In vitro In vivo Nitrile Rat Relation structure activité Récepteur dopaminergique D3 Synthèse chimique Sélectivité Voie orale 3-Benzoazépine-7-carbonitrile dérivé Cinnamamide(3-acétamido-N-[4-(2-[7-cyano-1,2,4,5-tétrahydro-3-benzoazépin-3-yl]éthyl)cyclohexyl]-2-fluoro) Cinnamique acide dérivé SB 277011 Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Animal Benzazepine derivatives Carboxamide Aromatic compound Bicyclic compound Vinylic compound Biological fixation Fluorine Organic compounds Nitrogen heterocycle In vitro In vivo Nitrile Rat Structure activity relation D3 Dopamine receptor Chemical synthesis Selectivity Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Animal Carboxamida Compuesto aromático Compuesto bicíclico Compuesto vinílico Fijación biológica Fluor Compuesto orgánico Heterociclo nitrógeno In vitro In vivo Nitrilo Rata Relación estructura actividad Receptor dopaminérgico D3 Síntesis química Selectividad Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 792772
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0960-894X(00)00505-9 
https://dx.doi.org/10.1016/S0960-894X(00)00505-9
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