Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α → hypoxia response element → VEGF cascade differentially regulates vascular response and growth rate in tumors
- Author
- TSUZUKI, Yoshikazu1 ; FUKUMURA, Dai1 ; OOSTHUYSE, Bert2 ; KOIKE, Chieko1 ; CARMELIET, Peter2 ; JAIN, Rakesh K1
[1] Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, United States
[2] Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, 3000, Belgium - Source
Cancer research (Baltimore). 2000, Vol 60, Num 22, pp 6248-6252 ; ref : 28 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Angiogenèse Animal Cellule tumorale Elément réponse Facteur angiogène Facteur croissance endothélium vasculaire Hypoxie In vitro In vivo Inducteur Lignée cellulaire établie Modulation Multiplication cellulaire Mécanisme action Néovascularisation Souris Transduction signal Tumeur maligne Facteur HIF1α Lignée ES Mammalia Rodentia Vertebrata
- Keyword (en)
- Angiogenesis Animal Tumor cell Response element Angiogenic factor Vascular endothelium growth factor Hypoxia In vitro In vivo Inductor Established cell line Modulation Cell proliferation Mechanism of action Neovascularization Mouse Signal transduction Malignant tumor Mammalia Rodentia Vertebrata
- Keyword (es)
- Angiogénesis Animal Célula tumoral Elemento respuesta Factor angiógeno Factor crecimiento endotelio vascular Hipoxia In vitro In vivo Inductor Línea celular establecida Modulación Multiplicación celular Mecanismo acción Neovascularización Ratón Transducción señal Tumor maligno Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04H Cell physiology / 002A04H17 Signal transduction
- Discipline
- Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 834257
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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