New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage : synthesis and preliminary in vitro and in vivo biological properties
- Author
- ETRYCH, Tomas1 ; JELINKOVA, Markéta2 ; RIHOVA, Blanka2 ; ULBRICH, Karel1
[1] Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovský Sq. 2, 162 06 Prague, Czech Republic
[2] Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic - Source
Journal of controlled release. 2001, Vol 73, Num 1, pp 89-102 ; ref : 21 ref
- CODEN
- JCREEC
- ISSN
- 0168-3659
- Scientific domain
- Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Animal Anthracyclines Anticancéreux Cathepsin B Chimiothérapie Composé conjugué Cytotoxicité Doxorubicine In vitro In vivo Libération Lymphome cellule T périphérique Méthacrylamide dérivé copolymère Polymère vecteur Propriété chimique Propriété physicochimique Souris Splénocyte Stabilité chimique Synthèse chimique Technologie pharmaceutique Traitement Vecteur médicament pH Cysteine endopeptidases Enzyme Hydrolases Hémopathie maligne Lymphome non hodgkinien Lymphoprolifératif syndrome Mammalia Peptidases Rodentia Vertebrata
- Keyword (en)
- Biological activity Animal Anthracyclins Antineoplastic agent Cathepsin B Chemotherapy Conjugated compound Cytotoxicity Doxorubicin In vitro In vivo Release Peripheral T cell lymphoma Methacrylamide derivative copolymer Control release polymer Chemical properties Physicochemical properties Mouse Splenocyte Chemical stability Chemical synthesis Pharmaceutical technology Treatment Drug carrier pH Cysteine endopeptidases Enzyme Hydrolases Malignant hemopathy Non Hodgkin lymphoma Lymphoproliferative syndrome Mammalia Peptidases Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Animal Antraciclinas Anticanceroso Cathepsin B Quimioterapia Compuesto conjugado Citotoxicidad Doxorubicina In vitro In vivo Liberación Linfoma célula T periférica Metacrilamida derivado copolímero Polímero vector Propiedad química Propiedad fisicoquímica Ratón Esplenocito Estabilidad química Síntesis química Tecnología farmacéutica Tratamiento Vector medicamento pH Cysteine endopeptidases Enzima Hydrolases Hemopatía maligna Linfoma no Hodgkin Linfoproliferativo síndrome Mammalia Peptidases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R02 Chemotherapy
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 981135
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/S0168-3659(01)00281-4 
https://dx.doi.org/10.1016/S0168-3659(01)00281-4
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