GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In VivoWALLIN, Jeffrey J; GUAN, Jane; PRIOR, Wei Wei et al.Clinical cancer research (Print). 2012, Vol 18, Num 14, pp 3901-3911, issn 1078-0432, 11 p.Article

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition proteinGOTTAR, Marie; GOBERT, Vanessa; MICHEL, Tatiana et al.Nature (London). 2002, Vol 416, Num 6881, pp 640-644, issn 0028-0836Article

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast CancerMCCLELAND, Mark L; ADLER, Adam S; BELVIN, Marcia et al.Cancer research (Chicago, Ill.). 2012, Vol 72, Num 22, pp 5812-5823, issn 0008-5472, 12 p.Article

In vivo Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer ModelsHOEFLICH, Klaus P; O'BRIEN, Carol; WEI ZHOU et al.Clinical cancer research (Print). 2009, Vol 15, Num 14, pp 4649-4664, issn 1078-0432, 16 p.Article

P21-Activated Kinase 1 (PAK1) as a Therapeutic Target in BRAF Wild-Type MelanomaONG, Christy C; JUBB, Adrian M; HARRIS, Adrian L et al.Journal of the National Cancer Institute. 2013, Vol 105, Num 9, pp 606-615, issn 0027-8874, 10 p.Article

Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid TumorsEDGAR, Kyle A; WALLIN, Jeffrey J; BERRY, Megan et al.Cancer research (Chicago, Ill.). 2010, Vol 70, Num 3, pp 1164-1172, issn 0008-5472, 9 p.Article

Intermittent Administration of MEK Inhibitor GDC-0973 plus PI3K Inhibitor GDC-0941 Triggers Robust Apoptosis and Tumor Growth InhibitionHOEFLICH, Klaus P; MERCHANT, Mark; ENGST, Stefan et al.Cancer research (Chicago, Ill.). 2012, Vol 72, Num 1, pp 210-219, issn 0008-5472, 10 p.Article

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthHATZIVASSILIOU, Georgia; KYUNG SONG; MORALES, Tony et al.Nature (London). 2010, Vol 464, Num 7287, pp 431-435, issn 0028-0836, 5 p.Article

Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAF^V600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway SuppressionHOEFLICH, Klaus P; HERTER, Sylvia; STERN, Howard et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 7, pp 3042-3051, issn 0008-5472, 10 p.Article

PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenograftsCHOO, Edna F; NG, Chee M; BERRY, Leanne et al.Cancer chemotherapy and pharmacology. 2013, Vol 71, Num 1, pp 133-143, issn 0344-5704, 11 p.Article

Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor ModelsJIE LIN; SAMPATH, Deepak; LEE, Leslie B et al.Clinical cancer research (Print). 2013, Vol 19, Num 7, pp 1760-1772, issn 1078-0432, 13 p.Article

Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic-Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK InhibitorWONG, Harvey; VERNILLET, Laurent; HOEFLICH, Klaus P et al.Clinical cancer research (Print). 2012, Vol 18, Num 11, pp 3090-3099, issn 1078-0432, 10 p.Article

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genomePARKS, Annette L; COOK, Kevin R; DEAL-HERR, Megan E et al.Nature genetics. 2004, Vol 36, Num 3, pp 288-292, issn 1061-4036, 5 p.Article