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In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation MechanismJIAN YU; BROWN, Dean G; BURDETTE, Doug et al.Drug metabolism and disposition. 2010, Vol 38, Num 10, pp 1767-1778, issn 0090-9556, 12 p.Article

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)VARNES, Jeffrey G; MARCUS, Andrew P; BROWN, Dean G et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 5, pp 1402-1406, issn 0960-894X, 5 p.Article

4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulatorsHUI XIONG; BRUGEL, Todd A; MCCAULEY, John P et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 24, pp 7381-7384, issn 0960-894X, 4 p.Article

SAR development of a series of 8-azabicyclo[3.2.1 ]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2BRUGEL, Todd A; SMITH, Reed W; GORDON, John et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 18, pp 5405-5410, issn 0960-894X, 6 p.Article

Acute pharmacological modulation of mGluR8 reduces measures of anxietyDUVOISIN, Robert M; PFANKUCH, Tim; WILSON, Julie M et al.Behavioural brain research. 2010, Vol 212, Num 2, pp 168-173, issn 0166-4328, 6 p.Article

Pyridazinoquinolinetriones as NMDA glycine-site antagonists with oral antinociceptive activity in a model of neuropathic painBARE, Thomas M; BROWN, Dean G; HERZOG, Keith J et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 13, pp 3113-3131, issn 0022-2623, 19 p.Article

Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5h )-triones as NMDA glycine-site antagonistsBROWN, Dean G; URBANEK, Rebecca A; XIAO, Wenhua et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 20, pp 3553-3556, issn 0960-894X, 4 p.Article

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activityBROWN, Dean G; MAIER, Donna L; TONGMING CHEN et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 11, pp 3399-3403, issn 0960-894X, 5 p.Article

Identification of Multiple Glutathione Conjugates of 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisopuinoline maleate (Nomifensine) in Liver Microsomes and Hepatocyte Preparations: Evidence of the Bioactivation of NomifensineJIAN YU; MATHISEN, Donald E; BURDETTE, Doug et al.Drug metabolism and disposition. 2010, Vol 38, Num 1, pp 46-60, issn 0090-9556, 15 p.Article

Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1BRUGEL, Todd A; SMITH, Reed W; CACCIOLA, Joseph et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 19, pp 5847-5852, issn 0960-894X, 6 p.Article

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