Replication increases β-cell vulnerability to human islet amyloid polypeptide-induced apoptosisRITZEL, Robert A; BUTLER, Peter C.Diabetes (New York, NY). 2003, Vol 52, Num 7, pp 1701-1708, issn 0012-1797, 8 p.Article

Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude ratsMATVEYENKO, Aleksey V; GEORGIA, Senta; BHUSHAN, Anil et al.American journal of physiology. Endocrinology and metabolism. 2010, Vol 62, Num 5, issn 0193-1849, E713-E720Article

Induction of endoplasmic reticulum stress-induced β-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptideHUANG, Chang-Jiang; HAATAJA, Leena; GURLO, Tatyana et al.American journal of physiology. Endocrinology and metabolism. 2007, Vol 56, Num 6, issn 0193-1849, E1656-E1662Article

Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased β-cell turnoverMEIER, Juris J; BUTLER, Alexandra E; GALASSO, Ryan et al.Diabetes care. 2006, Vol 29, Num 7, pp 1554-1559, issn 0149-5992, 6 p.Article

Induction of β-cell rest by a Kir6.2/SUR1-selective K_ATP-Channel opener preserves β-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucoseRITZEL, Robert A; HANSEN, John B; VELDHUIS, Johannes D et al.The Journal of clinical endocrinology and metabolism. 2004, Vol 89, Num 2, pp 795-805, issn 0021-972X, 11 p.Article

Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass: Dose-response relationshipsRITZEL, Robert A; VELDHUIS, Johannes D; BUTLER, Peter C et al.The Journal of clinical endocrinology and metabolism. 2003, Vol 88, Num 2, pp 742-747, issn 0021-972X, 6 p.Article

Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling PathwaysDAVAL, Marie; GURLO, Tatyana; COSTES, Safia et al.Diabetes (New York, NY). 2011, Vol 60, Num 4, pp 1186-1197, issn 0012-1797, 12 p.Article

Ongoing β-Cell Turnover in Adult Nonhuman Primates Is Not Adaptively Increased in Streptozotocin-Induced DiabetesSAISHO, Yoshifumi; MANESSO, Erica; COBELLI, Claudio et al.Diabetes (New York, NY). 2011, Vol 60, Num 3, pp 848-856, issn 0012-1797, 9 p.Article

β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 DeficiencyCOSTES, Safia; HUANG, Chang-Jiang; GURLO, Tatyana et al.Diabetes (New York, NY). 2011, Vol 60, Num 1, pp 227-238, issn 0012-1797, 12 p.Article

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-Induced β-Cell apoptosis in h-IAPP transgenic miceLIN, Chia-Yu; GURLO, Tatyana; KAYED, Rakez et al.Diabetes (New York, NY). 2007, Vol 56, Num 5, pp 1324-1332, issn 0012-1797, 9 p.Article

Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humansMEIER, Juris J; VELDHUIS, Johannes D; BUTLER, Peter C et al.Diabetes (New York, NY). 2005, Vol 54, Num 6, pp 1649-1656, issn 0012-1797, 8 p.Article

Pulsatile insulin secretion by human pancreatic isletsSONG, Soon H; KJEMS, Lise; RITZEL, Robert et al.The Journal of clinical endocrinology and metabolism. 2002, Vol 87, Num 1, pp 213-221, issn 0021-972XArticle

Direct measurement of pulsatile insulin secretion from the portal vein in human subjectsSONG, Soon H; MCINTYRE, Susan S; SHAH, Hasnain et al.The Journal of clinical endocrinology and metabolism. 2000, Vol 85, Num 12, pp 4491-4499, issn 0021-972XArticle

β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?COSTES, Safia; LANGEN, Ralf; GURLO, Tatyana et al.Diabetes (New York, NY). 2013, Vol 62, Num 2, pp 327-335, issn 0012-1797, 9 p.Article

β-Cell Mass and Turnover in Humans: Effects of obesity and agingSAISHO, Yoshifumi; BUTLER, Alexandra E; MANESSO, Erica et al.Diabetes care. 2013, Vol 36, Num 1, pp 111-117, issn 0149-5992, 7 p.Article

Beta-cell selective K_ATP-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicityRITZEL, Robert A; JAYASINGHE, Sajith; HANSEN, John B et al.Regulatory peptides. 2010, Vol 165, Num 2-3, pp 158-162, issn 0167-0115, 5 p.Article

Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With MetforminMATVEYENKO, Aleksey V; DRY, Sarah; COX, Heather I et al.Diabetes (New York, NY). 2009, Vol 58, Num 7, pp 1604-1615, issn 0012-1797, 12 p.Article

Diabetes due to a progressive defect in β-cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat): A new model for type 2 diabetesBUTLER, Alexandra E; JANG, Jennifer; GURLO, Tatyana et al.Diabetes (New York, NY). 2004, Vol 53, Num 6, pp 1509-1516, issn 0012-1797, 8 p.Article

Increased risk of type 2 diabetes in Alzheimer DiseaseJANSON, Juliette; LAEDTKE, Thomas; PARISI, Joseph E et al.Diabetes (New York, NY). 2004, Vol 53, Num 2, pp 474-481, issn 0012-1797, 8 p.Article

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes: Toxic Islet Amyloid Polypeptide Oligomers Form Intracellularly in the Secretory PathwayGURLO, Tatyana; RYAZANTSEV, Sergey; HUANG, Chang-Jiang et al.The American journal of pathology. 2010, Vol 176, Num 2, pp 861-869, issn 0002-9440, 9 p.Article

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer HypothesisHAATAJA, Leena; GURLO, Tatyana; HUANG, Chang J et al.Endocrine reviews. 2008, Vol 29, Num 3, pp 303-316, issn 0163-769X, 14 p.Article

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress-mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetesHUANG, Chang-Jiang; LIN, Chia-Yu; HAATAJA, Leena et al.Diabetes (New York, NY). 2007, Vol 56, Num 8, pp 2016-2027, issn 0012-1797, 12 p.Article

Mechanisms of impaired fasting glucose and glucose intolerance induced by a ∼50% pancreatectomyMATVEYENKO, Aleksey V; VELDHUIS, Johannes D; BUTLER, Peter C et al.Diabetes (New York, NY). 2006, Vol 55, Num 8, pp 2347-2356, issn 0012-1797, 10 p.Article

Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion : Further evidence for the intraislet insulin hypothesisMEIER, Juris J; KJEMS, Lise L; VELDHUIS, Johannes D et al.Diabetes (New York, NY). 2006, Vol 55, Num 4, pp 1051-1056, issn 0012-1797, 6 p.Article

The potential for stem cell therapy in diabetesMEIER, Juris J; BHUSHAN, Anil; BUTLER, Peter C et al.Pediatric research. 2006, Vol 59, Num 4, issn 0031-3998, 65R-73R, 2Article