Scalable Synthesis of the VEGF-R2 Kinase Inhibitor JNJ-17029259 Using Ultrasound-Mediated Addition of MeLi-CeCl₃ to a NitrileREUMAN, Michael; BEISH, Sandra; DAVIS, Jeremy et al.Journal of organic chemistry. 2008, Vol 73, Num 3, pp 1121-1123, issn 0022-3263, 3 p.Article

Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agentsRONGHUI LIN; CONNOLLY, Peter J; GRUNINGER, Robert H et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 15, pp 4297-4302, issn 0960-894X, 6 p.Article

1-acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors : Synthesis and evaluation of biological activities : 2005 American Chemical Society Award for Computers in Chemical and Pharmaceutical ResearchRONGHUI LIN; CONNOLLY, Peter J; MIDDLETON, Steven A et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 13, pp 4208-4211, issn 0022-2623, 4 p.Article

Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621SHENLIN HUANG; CONNOLLY, Peter J; RONGHUI LIN et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 14, pp 3639-3641, issn 0960-894X, 3 p.Article

Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptorBIGNAN, Gilles C; BATTISTA, Kathleen; CONNOLLY, Peter J et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 22, pp 5022-5026, issn 0960-894X, 5 p.Article

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3β inhibitorsKUO, Gee-Hong; PROUTY, Catherine; WESTOVER, Lori et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 19, pp 4021-4031, issn 0022-2623, 11 p.Article

Aminocyclohexylsulfonamides : Discovery of metabolically stable α_1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS)CHIU, George; SHENGJIAN LI; HONG CAI et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 22, pp 6123-6128, issn 0960-894X, 6 p.Article

Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitorsRONGHUI LIN; CHIU, George; YANG YU et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 16, pp 4557-4561, issn 0960-894X, 5 p.Article

SAR Maps : A New SAR Visualization Technique for Medicinal ChemistsAGRAFIOTIS, Dimitris K; SHEMANAREV, Maxim; CONNOLLY, Peter J et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 24, pp 5926-5937, issn 0022-2623, 12 p.Article

Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitorsSHENLIN HUANG; RONGHUA LI; CONNOLLY, Peter J et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 23, pp 6063-6066, issn 0960-894X, 4 p.Article

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitorsRONGHUI LIN; JOHNSON, Sigmond G; FUENTES-PESQUERA, Angel R et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 8, pp 2333-2337, issn 0960-894X, 5 p.Article

1 -Arylpiperazinyl -4 -cyclohexylamine derived isoindole-1,3-diones as potent and selective α-1a/1d adrenergic receptor ligandsSHENGJIAN LI; CHIU, George; PULITO, Virginia L et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 6, pp 1646-1650, issn 0960-894X, 5 p.Article

Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screeningORSINI, Michael J; KLEIN, Mark A; PAT BEAVERS, Mary et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 3, pp 462-471, issn 0022-2623, 10 p.Article

Synthesis of 3 -(1H -benzimidazol -2 -yl ) -5 -isoquinolin-4 -ylpyrazolo[1,2 -b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitorSHENLIN HUANG; RONGHUI LIN; YANG YU et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 5, pp 1243-1245, issn 0960-894X, 3 p.Article

Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitorsKUO, Gee-Hong; AIHUA WANG; JOHNSON, Dana et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 6, pp 1886-1900, issn 0022-2623, 15 p.Article

Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitorsKUO, Gee-Hong; PROUTY, Catherine; XIN CHEN et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 15, pp 4892-4909, issn 0022-2623, 18 p.Article

7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors : Design, synthesis, and biological activityHUGHES, Terry V; EMANUEL, Stuart L; O'GRADY, Harold R et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 18, pp 5130-5133, issn 0960-894X, 4 p.Article

A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity : Design, synthesis, and biological activityHUGHES, Terry V; GUOZHANG XU; MIDDLETON, Steven A et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 17, pp 4896-4899, issn 0960-894X, 4 p.Article

4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluationHUGHES, Terry V; EMANUEL, Stuart L; MIDDLETON, Steven A et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 12, pp 3266-3270, issn 0960-894X, 5 p.Article

3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo- [2,3-b]pyridines as ligands for the ORL-1 receptorBIGNAN, Gilles C; BATTISTA, Kathleen; CONNOLLY, Peter J et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 13, pp 3524-3528, issn 0960-894X, 5 p.Article

Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitorsSHENLIN HUANG; RONGHUA LI; CONNOLLY, Peter J et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 18, pp 4818-4821, issn 0960-894X, 4 p.Article

3-acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors : Synthesis and biological evaluationRONGHUI LIN; YANHUA LU; PANDEY, Niranjan et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 9, pp 2221-2224, issn 0960-894X, 4 p.Article

The in vitro and in vivo effects of JNJ-7706621 : A dual inhibitor of cyclin-dependent kinases and aurora kinasesEMANUEL, Stuart; RUGG, Catherine A; JOLLIFFE, Linda et al.Cancer research (Baltimore). 2005, Vol 65, Num 19, pp 9038-9046, issn 0008-5472, 9 p.Article

4-Aminopyrimidine-5-carbaldehyde oximes as potent VEGFR-2 inhibitors. Part IISHENLIN HUANG; RONGHUA LI; LAMONTAGNE, Kenneth R et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 6, pp 1815-1818, issn 0960-894X, 4 p.Article

A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivoLAMONTAGNE, Kenneth R; BUTLER, Jeannene; BOROWSKI, Virna B et al.Angiogenesis (London). 2009, Vol 12, Num 3, pp 287-296, issn 0969-6970, 10 p.Article