The immunogenicity of Bcr-Abl-expressing dendritic cells is dependent on the Bcr-Ab1 kinase activity and dominated by Bcr-Abl-regulated antigensSCHEICH, Florian; DUYSTER, Justus; PESCHEL, Christian et al.Blood. 2007, Vol 110, Num 7, pp 2556-2560, issn 0006-4971, 5 p.Article

BCR-ABL gene mutations in relation to clinical resistance of philadelphia-chromosome-positive leukaemia to STI571: a prospective studyVON BUBNOFF, Nikolas; SCHNELLER, Folker; PESCHEL, Christian et al.Lancet (British edition). 2002, Vol 359, Num 9305, pp 487-491, issn 0140-6736Article

Functional Analysis of Epidermal Growth Factor Receptor (EGFR) Mutations and Potential Implications for EGFR Targeted TherapyKANCHA, Rama Krishna; VON BUBNOFF, Nikolas; PESCHEL, Christian et al.Clinical cancer research (Print). 2009, Vol 15, Num 2, pp 460-467, issn 1078-0432, 8 p.Article

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation modelGRUNDLER, Rebekka; MIETHING, Cornelius; THIEDE, Christian et al.Blood. 2005, Vol 105, Num 12, pp 4792-4799, issn 0006-4971, 8 p.Article

Adhesion to fibronectin selectively protects Bcr-Abl⁺ cells from DNA damage-induced apoptosisVAN DER KUIP, Heiko; GOETZ, Alexander W; MIETHING, Cornelius et al.Blood. 2001, Vol 98, Num 5, pp 1532-1541, issn 0006-4971Article

Sequential Inhibitor Therapy in CML: In Vitro Simulation Elucidates the Pattern of Resistance Mutations after Second- and Third-Line TreatmentBAUER, Robert C; SÄNGER, Jana; PESCHEL, Christian et al.Clinical cancer research (Print). 2013, Vol 19, Num 11, pp 2962-2972, issn 1078-0432, 11 p.Article

Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)VON BUBNOFF, Nikolas; MANLEY, Paul W; MESTAN, Jurgen et al.Blood. 2006, Vol 108, Num 4, pp 1328-1333, issn 0006-4971, 6 p.Article

Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathwayBAI, Ren-Yuan; TAO OUYANG; MIETHING, Cornelius et al.Blood. 2000, Vol 96, Num 13, pp 4319-4327, issn 0006-4971Article

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase CδRINGSHAUSEN, Ingo; SCHNELLER, Folker; BOGNER, Christian et al.Blood. 2002, Vol 100, Num 10, pp 3741-3748, issn 0006-4971, 8 p.Article

Translocations involving anaplastic lymphoma kinase (ALK)DUYSTER, Justus; BAI, Ren-Yuan; MORRIS, Stephan W et al.Oncogene (Basingstoke). 2001, Vol 20, Num 40, pp 5623-5637, issn 0950-9232Article

Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptorGRUNDLER, Rebekka; THIEDE, Christian; MIETHING, Cornelius et al.Blood. 2003, Vol 102, Num 2, pp 646-651, issn 0006-4971, 6 p.Article

FMS-Like Tyrosine Kinase 3―Internal Tandem Duplication Tyrosine Kinase Inhibitors Display a Nonoverlapping Profile of Resistance Mutations In vitroVON BUBNOFF, Nikolas; ENGH, Richard A; ABERG, Espen et al.Cancer research (Chicago, Ill.). 2009, Vol 69, Num 7, pp 3032-3041, issn 0008-5472, 10 p.Article

Very severe iron-deficiency anemia in a patient with celiac disease and bulimia nervosa : A case reportJOST, Philipp J; STENGEL, Svenja M; HUBER, Wolfgang et al.International journal of hematology. 2005, Vol 82, Num 4, pp 310-311, issn 0925-5710, 2 p.Article

Imatinib and leptomycin B are effective in overcoming imatinib-resistance due to Bcr-Abl amplification and clonal evolution but not due to Bcr-Abl kinase domain mutationKANCHA, Rama Krishna; VON BUBNOFF, Nikolas; MIETHING, Cornelius et al.Haematologica (Roma). 2008, Vol 93, Num 11, pp 1718-1722, issn 0390-6078, 5 p.Article

The tyrosine phosphatase, SHP-1, is a negative regulator of endothelial superoxide formationKRÖTZ, Florian; ENGELBRECHT, Barbara; BUERKLE, Martin A et al.Journal of the American College of Cardiology. 2005, Vol 45, Num 10, pp 1700-1706, issn 0735-1097, 7 p.Article

An RNAi-based system for loss-of-function analysis identifies Raf1 as a crucial mediator of BCR-ABL―driven leukemogenesisALBERS, Corinna; ILLERT, Anna L; MIETHING, Cornelius et al.Blood. 2011, Vol 118, Num 8, pp 2200-2210, issn 0006-4971, 11 p.Article

ITD- and FL-induced FLT3 signal transduction leads to increased C/EBPβ-LIP expression and LIP/LAP ratio by different signalling modulesHAAS, Sandra C; HUBER, René; GUTSCH, Romina et al.British journal of haematology. 2010, Vol 148, Num 5, pp 777-790, issn 0007-1048, 14 p.Article

Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptorBREITENBUECHER, Frank; SCHNITTGER, Susanne; GRUNDLER, Rebekka et al.Blood. 2009, Vol 113, Num 17, pp 4074-4077, issn 0006-4971, 4 p.Article

Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60^c-src to mediate its mitogenicityCUSSAC, Daniel; GREENLAND, Catherine; ROCHE, Serge et al.Blood. 2004, Vol 103, Num 4, pp 1464-1471, issn 0006-4971, 8 p.Article

SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AMLLEISCHNER, Hannes; ALBERS, Corinna; GRUNDLER, Rebekka et al.Blood. 2012, Vol 119, Num 17, pp 4026-4033, issn 0006-4971, 8 p.Article

Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571)WOHLBOLD, Lara; VAN DER KUIP, Heiko; MIETHING, Cornelius et al.Blood. 2003, Vol 102, Num 6, pp 2236-2239, issn 0006-4971, 4 p.Article

Primary Central Nervous System Lymphoma in a Patient Treated With NatalizumabSCHWEIKERT, Andreas; KREMER, Marcus; RINGEL, Florian et al.Annals of neurology. 2009, Vol 66, Num 3, pp 403-406, issn 0364-5134, 4 p.Article

The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation modelMIETHING, Cornelius; GRUNDLER, Rebekka; FEND, Falco et al.Oncogene (Basingstoke). 2003, Vol 22, Num 30, pp 4642-4647, issn 0950-9232, 6 p.Article

Analysing c-kit internalization using a functional c-kit-EGFP chimera containing the fluorochrome within the extracellular domainJAHN, Thomas; SEIPEL, Petra; COUTINHO, Sunita et al.Oncogene (Basingstoke). 2002, Vol 21, Num 29, pp 4508-4520, issn 0950-9232, 13 p.Article

Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosisGREENLAND, Catherine; TOURIOL, Christian; CHEVILLARD, Grégory et al.Oncogene (Basingstoke). 2001, Vol 20, Num 50, pp 7386-7397, issn 0950-9232Article